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What is the normal life span of RBCs?
120 days
What are the 3 mechanisms of anemia?
Ineffective Erythropoiesis
Insufficient Erythropoiesis
Blood Loss / Hemolysis
Which mechanism of anemia involves the production of erythroid precursor cells that are DEFECTIVE?
INEFFECTIVE Erythropoiesis
What happens to the defective precursors in Ineffective Erythropoiesis
The precursors undergo APOPTOSIS
What 3 diseases are associated with Ineffective Erythropoiesis?
MEGALOBLASTIC Anemia
Thalassemia
Sideroblastic anemia
Which mechanism of anemia is associated with DECREASED RBC production?
INSUFFICIENT Erythropoiesis
Which 2 diseases are correlated with INSUFFICIENT Erythropoiesis?
EPO Deficiency
Iron Deficiency
Which mechanism of Anemia is associated with the LOSS or DESTRUCTION of RBCs?
HEMOLYSIS / Blood loss