Week 6 - Dosage Compensation

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9 Terms

1
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Dosage Compensation - Mammals

Inactivate 1 X in females

2
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Xic

Regions on X which codes for Xist RNA

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Before Inactivation

Unstable Xist RNA

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Inactivation Process

Xist upregulated + stabilised

Xist RNA coat X

Transcriptional silencing

DNA/histone modifications/methylation - condense

Barr body

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Tortoiseshell Coloured Cats - Process

XX diff alleles

Randomly inactivated

Patches

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Tortoiseshell Cats - Colours

Black

Red/orange

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Drosophilia - Dosage Compensation

Double transcription single X in male

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Marsupials - Dosage Compensation

Always inactivate paternal X

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Nematodes - Dosage Compensation

Halve both XX