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Dosage Compensation - Mammals
Inactivate 1 X in females
Xic
Regions on X which codes for Xist RNA
Before Inactivation
Unstable Xist RNA
Inactivation Process
Xist upregulated - stable
Xist RNA coat X
Transcriptional silencing
Condense
Barr body
Tortoiseshell Coloured Cats - Process
XX diff alleles
Randomly inactivated
Patches
Tortoiseshell Cats - Colours
Black
Red/orange