blood bank 1

pertaining to a chromosome that is not a sex chromosome

autosomal

gene mutation is present on a sex chromosome

sex linked

one variant of a gene on a chromosome masking or overriding the effect of a different variant

dominant

relating to two alleles of a gene that are both fully expressed

codominant

an allele that does not produce a characteristic effect when present with a dominant allele

recessive

sequence of DNA that is inherited

genotype

expression of the genotype

phenotype

at each locus there may be only one or several different forms of the gene

allele

presence of two identical alleles

homozygous

inheritance of different alleles

heterozygous

effect of a significant difference in antibody reaction depending on the quantity of the target antigen present on a target RBC

dosage

most blood group genes are inherited in an _______ manner

autosomal dominant or codominant

the segregation of the parents gene copies during the formation of reproductive cells occurs during

meiosis

when genes for separate traits are closely linked on a chromosome, they can be inherited together as a single unit

linkage

example of linkage

MNSs

a square diagram used to predict the genotypes of a particular cross or breeding event

punnett square

inheritance on the same chromosome

cis

inheritance on the opposite chromosome

trans

inheriting antigens from each parent as a unit due to linkage

haplotype

specific location of a gene on a chromosome

locus

one chromosome has a copy of the gene and the other chromosome has that gene deleted or absent

hemizygous

males are

square

females are

circle

vertical line

offspring

double line

consanguineous mating

stillbirth or abortion

small black circle

most interesting or important member of pedigree indicated by an arrow

prospositus

prevalence at the genetic level, occurrence of an allele in a population

frequency

occurrence of a permanent inherited characteristic at the phenotype level in any given population

prevalence

the rate of occurrence in a population of a condition that changes over time

incidence

can estimate allele frequencies based on observations of phenotypes in a large number of individuals in a sample population

hardy wienberg

hardy weinberg equation

$$\left(p+q\right)^2=p^2+2pq+q^2=1$$

p²

AA

2pq

Aa

q²

aa

(p+q)(p+q)=

1

antigen frequencies vary with

race

gene and phenotype frequencies are based on

probability

A patient has an anti-E and anti-K.  How many units of ABO compatible RBCs must be tested to find three compatible units?

Approx 30% of population E positive

•(70% E negative)

•Approx 10% of population K positive

•(90% K negative)

63% or 3/5