VM 704- (Physiology) Muscle Physiology
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15 Terms
What are the 3 main sources that produce ATP for muscle contraction?
Creatine phosphate breakdown
Glycolysis
Cellular respiration
What are the 2 elements required in Excitation-Contraction coupling?
Calcium and ATP.
What is the role of the Gq protein in smooth muscle contraction?
It produces IP3 which then releases calcium into the sarcoplasmic reticulum.
What is the role of the Gq protein in smooth muscle contraction?
It adds cAMP, inhibiting MLCK, which triggers relaxation.
What is the role of the Gi protein in smooth muscle contraction?
It removes cAMP, preventing inhibition of MLCK, triggering contraction.
What is the pump that uses ATP to bring calcium into its storage site?
The SERCA pump.
What moves to bring Z lines together during a muscle contraction?
The thin filaments.
Physiologically, what causes muscle hypertrophy?
An increase in the SIZE of muscle cells.
Physiologically, what causes muscular dystrophy?
A loss of myofibril attachment to the sarcolemma.
Physiologically, what causes myasthenia gravis?
Acetylcholine is released normally, but it can’t bind to the nAChR.
Physiologically, how can myasthenia gravis be treated?
By giving a drug in the form of an AChE inhibitor.
How does lidocaine affect muscle contraction?
It blocks voltage gated Na+ channels.
How does myasthenia gravis affect muscle contraction?
It produces antibodies to nAChR.
How does botulinum toxin affect muscle contraction?
It prevents the release of Ach.
How does larkspur affect muscle contraction?
It acts as a competitive antagonist of nAChR.