Acute vs long term effects - in progress

Causes lyme disease, spirochete, transmitted by Ioxdes

Borrelia burgdorferi

Does a positive antibody test for Borrelia mean an animal has lymes disease?

No, there may have been prior exposure

Borrelia burgdorferi acute sysmptoms

fever, lameness

Borrelia burgdorferi chronic syndromes

Lameness, glomerulonephropathy

How do we test for Borrelia burgdorferi

4dx snap test

What is the tropism for canine distemper virus?

Almost all tissue, moves from macrophages to lymphoid tissue and spreads to epithelial tissue

How is canine distemper transmitted?

From dog to dog, it does not persist in the environment

Acute symptoms of distemper

fever, leukopenia

Chronic symptoms of distemper

CNS invasion, old dog encephalitis, nasal and footpad hyperkeratosis

What is a telltale sign of prior CDV infection?

Enamal hypoplasia “cement lines”

What are the primary hosts of Dirofilaria immitis? What are some secondary hosts?

Domestic dogs are primary, other hosts can be ferrets, cats, marine mammals and people

Acute symptoms of Dirofilaria immitis

mycardial injury and heart failure, death

Chronic symptoms of Dirofilaria immitis

glomerulonephritis, proteinuria, right heart enlargement and failure

Is mycardial injury and heart failure associate with acute or chronic heart worm infection?

Both

How long does it take for microfilaria to be detected in a patient after Dirofilaria immitis infection? How long can worms live during chronic infection?

6-7 months, HW can live 5-7 years

If a dog is treated for heartworm promptly, will they avoid all chronic future effects? If not, what are the potential chronic effects?

No, renal damage/dysfunction, myocardial injury and heart failure

A young dog presents with low BCS, pendulous abdomen and a chem reveals end stage liver failure, what disease might have these chronic effects?

Leptosporosis

Spirochete bacteria, can cause kidney and liver damage, acute infection can go unnoticed but end in liver failure

Leptospirosis

Granulomatous hepatitis with fibrosis and nodular hyperplasia may be negative for leptospirosis, but still be caused by lepto. Why?

Prior infection may have been cleared, but damage was done to the liver that caused chronic, long term issues