Chp 21 - Fatty Acid Degradation

exam 3

oxidation of fatty acids is a major energy source in many organisms

true

where are fatty acids stored and as what?

fatty acids are stored in adipose tissue as triacylglycerols (TAG)

how do we access fatty acids from adipose tissue?

1. degradation of triacylglycerol to release fatty acids + glycerol

   • these get released into the blood for transport to energy-requiring tissues

2. activation of fatty acids and transport into the matrix of the mitochondria for oxidation

3. degradation of the fatty acids to acetyl CoA for processing by the CAC

first step of fatty acid degradation → degradation of triacylglycerol to release fatty acids and glycerol

what activates glycerol?

glycerol kinase

fats are degraded into fatty acids and glycerol in the _________ of adipocytes

cytoplasm

how are fatty acids transported to other tissues for fuel?

through the blood

where does beta oxidation of fatty acids occur?

the mitochondria

small fatty acids diffuse freely across mitochondrial membranes, but larger fatty acids are transported via…

carnitine/acyl-carnitine transporter

fatty acid activation is the formation of…

the fatty acyl CoA

fatty acid activation

fatty acid → fatty acyl CoA occurs in how many steps? what are the enzymes that catalyze these steps?

two, fatty acyl-CoA synthetase and inorganic pyrophosphatase

fatty acid enters the mitochondria after activation via…

acyl-carnitine/carnitine transporter

fatty acids are degraded into _______-____ via __ ____________

acetyl-CoA, beta-oxidation

now converted into acetyl CoA, acetyl CoA can enter the…

citric acid cycle