Immunology Important transcription factors

What are the transcription factors involved in the Immune response?

NF-KB and IRFs

What are the transcription factors involved in T-helper cells?

FOXP3, T-bet, GATA3, RORyt, and BCL-6

FoxP3 function

Treg development, maintaining an anti-inflammatory environment.

What inflammatory stimuli cause the breakdown of FoxP3?

TNF and IL6

RORyt function

defining transcription factor for Th17, maintains inflammation

what happens when there is dysregulation of RORyt and Th17 cells?

inflammatory diseases and autoimmune disorders

Treatments for autoimmune disorders or inflammatory diseases target _______.

RORyt

GATA3 function

defining transcription factor for Th2 t-helper cells

stabilizes type 2 immunity via feedback loop

GATA3 is involved in the maturation of ___ cells, ___ cells, and ___ cells.

T, NK, ILC

Tbet Function

defining transcription factor for Th1

Tbet expression inhibits ____ expression, preventing type __ response.

GATA3, 2

Tbet regulates the expression of

cytotoxic mediators such as granzymes, granulysin, perforin

BCL-6 function

inhibits any other genes that produce any other T cell than Tfh (t-folicular)

Dysregulation of Tfh is associated with

autoantibody-mediated autoimmune response

HIF-1α function

transcription factor that is activated in hypoxic conditions

switches cellular metabolism during infection

highly expressed in tumors

Anti-tumoral treatments target the ____ gene.

HIF-1α

High expression of HIF-1α causes overexpression of ____, which prevents neutrophils from killing bacteria

NETs