Solution:
The correct answer is E.
It is possible that pq = −2, since −2 × −2 = 4, so answer choices A and B can be eliminated. For answer choice C, it is possible that if the product of two numbers is 2 or −2, one of the numbers is a fraction. For example it could be that p=12 and q=4. Similarly, for answer choice D, p and q could have the same sign or different signs, so this may or may not be true. Finally, in choice E, if p is larger than 2, then you would need to multiply it by something smaller to get a final product of 2. As an example, suppose that p = 3. Since pq = 2, then q=23. This makes answer choice E the only statement that would always be true.