Central Dogma Quiz 1

Which molecule serves as the starting molecule for de novo purine nucleotide synthesis?

Ribose-5-phosphate

In de novo purine synthesis, inosine monophosphate (IMP) serves as the precursor for:

AMP and GMP

Which nucleotide is the first fully formed pyrimidine nucleotide produced in de novo synthesis?

UMP

Which statement correctly compares purine and pyrimidine de novo synthesis?

Purines are built on PRPP; pyrimidines are synthesized first and attached later

The enzyme HGPRT salvages which purine bases?

Guanine and hypoxanthine

The anticancer drug 5-fluorourail (5-FU) inhibits this reaction:

dUMP → dTMP

Which carbon of the ribose sugar is reduced by the enzyme ribonucleotide reductase?

2'

Cytidine triphosphate (CTP) is synthesized directly from:

UTP

Refer to the DNA infographic.

Helicase:

B

Refer to the DNA infographic.

Irinotecan acts here:

A

Refer to the DNA infographic.

This corresponds to 3' end of tempplate DNA:

F

Refer to the DNA infographic.

RNA primer:

C

Refer to the DNA infographic.

Okazaki Fragment:

D

Refer to the DNA infographic.

Leading strand synthesis:

E

Each of the following represent a critical component of PCR except:

Four deoxynucleosides

Which letter corresponds to the product resulting from addition of a poly-A tail?

J

Which letter corresponds to the product of splicing?

K

Which nomenclature association is false?

Sense = Template strand

If mRNA has the following sequence: 5'-AUUCAGCACC-3'; then the corresponding antisense strand of DNA would read:

3' TAAGTCGTGG 5'

Which statement is false regarding Nucleoside HIV Reverse Transcriptase Inhibitors (NRTis)?

Contain a 3'-OH group

The DNA content of an organism was found to contain 16% A. Therefore, the % of G would be:

34

Upon heating a sample of DNA to around 95 oC, a sharp increase in absorbance at 260-nm wavelength range indicates:

DNA denaturing correlating to double helix strand separation.

Which of the following matched pairs (process: initiator of process) is incorrect?

PCR: DNA primers + RNA primase

Which statement is incorrect for mitochondrial DNA (mTDNA)?

is linear dsDNA

Which statement is false regarding mRNA transcription and processing?

Exons are removed from pre mRNA by a process called splicing

Which statement is false regarding mRNA transcription and processing?