Lecture 9a RBC morphology (copy)

What is defined as a variation in the RBC SIZES

Anisocytosis

What is defined as a variation in the RBC SHAPES

Poikilocytosis

Which 3 anemias can be seen in Anisocytosis?

1. Iron deficiency anemia

2. Megaloblastic anemia

3. Hemolytic anemia

Severe anemia is associated with which RBC abnormality?

Poikilocytosis

Which RBC value dictates if anisocytosis is present?

RDW

Which RBC Abnormality is seen in the image?

Anisocytosis

Which RBC Abnormality is seen in the image?

Poikilocytosis

Which is defined by having LARGE RBCs and an MCV >100

MACROcytosis

Which RBC Abnormality is seen in the following image?

Macrocytosis

Which 3 conditions can cause MACROCYTOSIS?

1. Megaloblastic anemia

2. Liver Disease

3. Bone Marrow failure

Which is defined by having SMALL RBCs and an MCV <80

MICROcytosis

Which RBC Abnormality is seen in the image?

Microcytosis

Which diseases cause MICROcytic abnormalities? (THIALS)

T = Thalassemia

H = Hb E Disease

I = Iron deficiency anemia

A = Anemia of chronic inflammation

L = Lead poisoning

S = Sideroblastic anemia

Which RBC Abnormality is associated with being SMALL, Spherical, CONDENSED (no central pallor)?

Spherocyte

Which RBC Abnormality is seen in the image?

Spherocyte

Which RBC Abnormality is associated with SEVERE BURNS and Immune hemolytic anemia

Spherocyte

Which RBC Abnormality is associated with having an ELLIPTICAL or OVAL shape?

Elliptocytosis or Ovalocytosis

Which RBC abnormality is seen in the image?

Elliptocytosis & Ovalocytosis

Which 3 diseases are linked with Elliptocytosis/Ovalocytosis?

1. Iron deficiency anemia

2. Myelophthisic anemias

3. Thalassemia

Which RBC Abnormality is associated with a SLIT LIKE area in the central pallor?

Stomatocyte

Which RBC Abnormality is seen in the image?

Stomatocyte

Which RBC Abnormality is associated with Alcoholism, Liver Disease, & Rh deficiency anemia?

Stomatocyte

Which RBC Abnormality is associated with a THIN ELONGATED/CURVED structure with pointed ends?

Sickle Cell

Which RBC Abnormality is seen in the image?

Sickle cell

Which 2 diseases is associated with Sickle Cells (dont overthink it)

1. Sickle cell ANEMIA

2. Sickle Cell Beta thalassemia

Which RBC abnormality can be characterized by an ENLARGED HEXAGONAL shape / Dark pill shape?

Hb C Crystal

Which RBC abnormality is seen in the image?

Hb C Crystal

Think C for Cystine which is hexagonal shape

Which RBC abnormality is associated with Hb C Disease?

Hb C Crystal

Which RBC Abnormality is characterized by FINGER like shape or Washington monument?

Hb SC crystal

Which RBC Abnormality is seen in the image?

Hb SC Crystal

Which RBC Abnormality is seen with Hb SC Disease?

Hb SC Crystal

Which RBC abnormality is characterized by a TARGET RBC?

Target Cell (Codocyte)

Which RBC abnormality is seen in the image?

Codocyte / Target Cell

Which RBC abnormality is characterized by Liver disease and Hemoglobinopathies?

Target Cell

Which RBC abnormality is characterized as a FRAGMENTED/ Ruptured RBC?

Schistocyte

Which RBC abnormality is seen in the image?

Schistocyte

Which other RBC abnormality is associated with EXTENSIVE BURNS & Hemolytic anemia

Schistocytes

Which RBC abnormality is characterized as FRAGMENTED with a HELMET shape?

Helmet Cell / Keratocyte

Which RBC abnormality is seen in the image?

Helmet Cell / Keratocyte

Which diseases are associated with the Helmet Cell RBC abnormality?

Extensive burns & Hemolytic anemia

SAME AS SCHISTOCYTE

Which RBC abnormality is characterized as being SMALL & DENSE with IRREGULAR projections?

Acanthocyte / Spur Cell

Which RBC abnormality is seen in the image?

Acanthocyte / Spur Cell

Which RBC abnormality is associated with SEVERE liver disease & Neuroacanthocytosis?

Acanthocyte / Spur Cell

Which RBC abnormality is characterized as having BLUNT small protrusions with a GEAR look / SHIVERING look?

Burr Cell / Echinocyte

Which RBC abnormality is seen in the image?

Burr Cell / Echinocyte

Which RBC abnormality is associated with UREMIA & Pyruvate Kinase deficiency?

Burr cell / echinocyte

Which RBC abnormality is characterized by having a TEAR DROP shape?

Tear drop cell (dacrocyte)

Which RBC abnormality is seen in the image?

Teardrop cell

Which RBC abnormality is associated with Primary myelofibrosis & Megaloblastic anemia?

Teardrop cell