Extended - Quiz 2: Top 300

Aspirin’s Brand

Vazalore, Bayer

Diclofenac Gel’s Brand

Voltaren, Cambia, Zipsor, Zorvolex

Lidocaine Patch’s Brand

Lidoderm, Lidotral

Ibuprofen’s Brand

Motrin, Advil

Naproxen’s Brand

Naprosyn, Aleve

Indomethacin’s Brand

Indocin, Tivorbex

Meloxicam’s Brand

Mobic

Celecoxib’s Brand

Celebrex

Acetaminophen’s Brand

Tylenol

Carisoprodol’s Brand

Soma, Vanadom

Cyclobenzaprine’s

Flexeril

Methocarbamol’s Brand

Robaxin, Tanlor

Metaxalone

Skelaxin

Aspirin Therapeutic Class

Salicylate

Diclofenac Gel Therapeutic Class

NSAID

Lidocaine Path Therapeutic Class

Local Anesthetic

Ibuprofen Therapeutic Class

NSAID

Naproxen Therapeutic Class

NSAID

Indomethacin Therapeutic Class

NSAID

Meloxicam Therapeutic Class

NSAID

Celecoxib Therapeutic Class

COX-2 Inhibitor

Acetaminophen Therapeutic Class

Analgesic

Carisoprodol Therapeutic Class

Centrally Acting Skeletal Muscle Relaxant (C-IV)

Cyclobenzaprine Therapeutic Class

Centrally Acting Skeletal Muscle Muscle Relaxant

Methocarbamol Therapeutic Class

Centrally Acting Skeletal Muscle Relaxant

Metaxalone Therapeutic Class

Centrally Acting Skeletal Muscle Relaxant

Aspirin MOA

Inhibits Platelet Aggregation By Irreversibly Inhibiting COX (Preventing Production of Thromboxane A[2] Which is A Powerful Inducer of Platelet Aggregation and Vasoconstriction)

Diclofenac Gel MOA

Non-Selective COX-1 and COX-2 Inhibitor, Blocks specific enzymes that trigger pain and swelling at the application site

Lidocaine Patch MOA

Targets the peripheral nervous system and relieves pain by blocking sodium channels in nerve endings directly beneath the skin

Ibuprofen MOA

Non-Selective COX-1 and COX-2 Inhibitor, Reversibly Alters Platelet Function and Prolongs Bleeding Time

Naproxen MOA

Non-Selective COX-1 and COX-2 Inhibitor

Indomethacin MOA

Non-Selective COX-1 and COX-2 Inhibitor, Reversibly Alter Platelet Function and Prolongs Bleeding Time

Meloxicam MOA

Non-Selective COX-1 and COX-2 Inhibitor, Results In Decreased Formation of Prostaglandin Precursors, Reversibly Alters Platelet Function, and Prolongs Bleeding Time (Has Antipyretic, Analgesic, and Anti-Inflammatory Properties)

Celecoxib

Inhibits COX-2 Enzyme Isoform Which Is Thought To Be Responsible For Anti-Inflammatory Effects of NSAIDs

Acetaminophen MOA

Centrally Acting Analgesic and Antipyretic With Minimal Anti-Inflammatory Properties, Mechanism is Unknown But May Be Through Central Inhibition of Prostaglandin Synthesis

Carisoprodol MOA

Block Intraneuronal Activity in Descending Reticular Formation and Spinal Cord, Results in Muscle Relaxation

Cyclobenzaprine MOA

Relieves Skeletal Muscle Spasm of Local Origin Without Interfering With Function Function But Is Ineffective In Muscle Spasm Due To CNS Disease, Evidence Suggests That Net Effect Drug Is A Reduction In Tonic Motor Activity Influencing Both Gamma and Alpha Motor Systems

Methocarbamol MOA

Has Not Been Established In Humans, May Be Due To General CNS Depression, There Is No Direct Action On The Contractile Mechanism Of Striated Muscle, The Motor End Plate, Or The Nerve Fiber

Metaxalone MOA

Has Not Been Established In Humans, May Be Due To General CNS Depression, There Is No Direct Action On The Contractile Mechanism Of Striated Muscle, The Motor End Plate, Or The Nerve Fiber

Aspirin Adult Starting Dose

325 to 625 mg po q6h prn [max 4 g/d]

Diclofenac Gel Adult Starting Dose

50 mg po tid prn [max 200 mg/d]

Lidocaine Patch Adult Starting Dose

1 to 3 Patches (12 h on, 12 h off)

Ibuprofen Adult Starting Dose

200 to 400 mg po q4-6h prn [max1,200 mg/d OTC and 3,200 mg/d Rx]

Naproxen Adult Starting Dose

500 mg po q 12h prn [max 1,000-1,500 mg/d Rx]

Indomethacin Adult Starting Dose

50 mg po bid-tid [max 200 mg/d]

Meloxicam Adult Starting Dose

7.5 mg po daily [15 mg/d]

Celecoxib Adult Starting Dose

100 mg bid or 200 mg po daily; for migraine acute treatment 120 mg po single dose [max 400 mg/d]

Acetaminophen Adult Starting Dose

325 to 650 mg po q4-6h or 1,000 mg po q6h prn [max 3,000-3,500 mg/d]

Carisoprodol Adult Starting Dose

250 to 350 mg po tid hs [max 1,400 po mg/d]

Cyclobenzaprine Adult Starting Dose

5 mg po tid

Methocarbamol Adult Starting Dose

1,500 mg po tid-quid for 48-72 h [max 4,500 mg/d]

Metaxolone Adult Starting Dose

800 mg po tid-qid