Vancomycin, Baclofen, cyclobenzaprine, phenelzine, TCA

What is vancomycin effective in

C.DIFF, MRSA AND STAPH (GRA POSITIVE BACTERIA)

HOW DOES IT WORK

IT INHIBITS THE ENZYME NECESSARY FOR CELL WALL FORMATION

ADVERSE EFFECTS OF VANCOMYCIN

OTOTOXICITY, KIDNEY DAMAGE, THROMBOPHLEBITIS(iv INFILTRATION)

WHAT SHOULD THE NURSE MONITOR for vancomycin

Administer at a minimum over 1 hour to prevent red man syndrome

Monitor through levels

How does Baclofen work

It increases the inhibitory effects of GABA.

Relieves muscles spasticity due to cerebral palsy

Side effects of baclofen

CNS effects and withdrawal symptoms if stopped abruptly.

Baclofen and diabetics

Diabetics may need to increase meds due to increase in blood glucose

Nursing considerations for Baclofen

Check renal function, increase fluids and fibers for constipation

No CNS depressants(no alcohol)

Do not stop abruptly

Take with food or milk

cYCLOBENZAPRINE (Flexeril)

The med dad takes lol.

MAkes GABA work better.

IT is a CNS drug

Adverse effects

Dizziness, drowsiness, constipation, nausea.

Nursing considerations

Increase fluids and fibers

NO MAOI within two weeks. Not for patients with cerebral palsy/urinary retention.

no alcohol

Phenylzine

“zine=sin=MAOI, the biggest hated drug.

It blocks monoamine oxidase so increases serotonie, dopamine and norepinephrine

Contraindications of phenelzine

Renal failure, liver disease or taking SSRIs

Client instruction for those taking Phenelzine

DO not eat food with thyramine

report if you get agitated, insomnia or anxiety

Drug interaction with phenelzine

tricylic anti depressants, sympathomimetic drugs, thyramine.

SSRIs can cause serotonin syndrome

What foods are high in thyramine

Beans, nuts, cheese, wine, tofu, preserved meats

How does Amitriptyline TCA work

increase serotonin and norepinephrine by inhibiting their reuptake in post synaptic gap

when do you give amitriptyline

Give orally at bedtime

Therapeutic effects may take weeks

Client instructions for amitryptiline

Do not drive until effects are knowns

HARD CANDY for dry mouth

Fluids and fiber for constipation

do not stop abruptly

Contraindications for TCA

Cardiac problems

MAOIS

Interactions TCA

Lev/carbi can increase sympathomimetic effects

anticholinergic drugs

other cns depressants