Lecture 12 a Quantitative Abnormalities of Leukocytes
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36 Terms
What is Neutrophil RELATIVE COUNT?
This number is a PERCENTAGE
What is the normal relative count range for neutrophils?
50%-70%
What is NEUTROPHILIA?
Increased Neutrophils, associated with a higher ANC
What is the NORMAL ANC range?
1.7 - 7.5
What does an ANC <1.7 indicate?
NeutroPENIA
What is Neutropenia?
DECREASED neutrophils
ANC <1.7
Which will increase the risk of infection, Neutropenia or Neutrophilia?
NeutroPENIA increases infection risk as we don’t have enough neutrophils
What is the formula for calculating ANC/other Absolute Counts?
(Total Neutrophils or other leukocyte)/100 x WBC
What is a LEFT SHIFT?
The release of IMMATURE WBCs
What does a Left Shift cause?
What is Agranulocytosis?
Nearly NO NEUTROPHILS
What is the ANC value for Agranulocytosis?
<0.5
Normal ANC range is 1.7-7.5
What is seen in a Leukemoid Reaction?
HIGH INCREASE in leukocyte count and LEFT SHIFT
What is seen in a Leukoerythroblastic reaction?
Increase in IMMATURE WBCs and RBCs associated with PRIMARY MYELOFIBROSIS
What kind of reaction is Primary Myelofibrosis associated with?
Leukoerythroblastic reaction
What is the normal RELATIVE COUNT of Eosinophils?
1-3%
What is the normal range for AEC?
0.09 - 0.4
What is Eosinophilia?
INCREASE in Eosinophils
What is the AEC value for Eosinophilia?
>0.4
Normal range is 0.09-0.4
What are the 2 main things that can cause EOSINOPHILIA?
Parasitic Infections
Allergic DISRODERS
What is Eosinopenia?
DECREASED Eosinophils
What is the AEC value for Eosinopenia?
<0.09
Normal Range is 0.09-0.4
What is the normal RELATIVE range for Basophils?
0-2%
What is Basophilia?
INCREASE in Basophils
>0.15 ABC
What is the ABC value for Basophilia?
ABC > 0.15
Which leukemia is BASOPHILIA associated with?
Chronic Myelogenous Leukemia (CML)
What is the normal RELATIVE COUNT for Monocytes?
2-11%
What is the normal AMC range?
0.2 - 1
What is Monocytosis?
INCREASE in monocytes
AMC > 1.0
What is the AMC value for Monocytosis?
AMC > 1.0
What is Monocytopenia
DECREASE in monocytes
AMC <0.2
What is the AMC value for Monocytopenia?
AMC < 0.2
normal range is 0.2-1.0
Which age group typically has a bigger amount of Lymphocytes present?
CHILDREN/BABIES
What is the ALC for Lymphocytosis?
ALC > 4.5
What can Whooping cough, EBV, and CMV cause?
Lymphocytosis
What is considered Lymphocytopenia in Children vs adults?
Children = ALC <2
Adults = ALC <1