Set 2: The Three Pathways of Complement Activation

Q14. What are the three pathways of complement activation? a) Alternative, lectin, classical b) Innate, adaptive, memory c) Primary, secondary, tertiary d) Direct, indirect, mixed

a

Q15. Which pathway is spontaneous and already initiated and ready to go whenever a pathogen enters the body? a) Lectin pathway b) Classical pathway c) Alternative pathway d) All of the above

c

Q16. Which pathway is activated by recognition of bacterial oligosaccharides ending in mannose or fucose? a) Alternative pathway b) Lectin pathway c) Classical pathway d) None of the above

b

Q17. Which pathway is best activated by antibodies bound to pathogen surface? a) Alternative pathway b) Lectin pathway c) Classical pathway d) All of the above

c

Q18. What is the order of action for the three pathways (first to act to last)? a) Classical → Lectin → Alternative b) Alternative → Lectin → Classical c) Lectin → Classical → Alternative d) Alternative → Classical → Lectin

b

Q19. All three pathways converge on the formation of what? a) C3 convertase b) C5 convertase c) Membrane attack complex d) C1 complex

a

Q20. What is the C3 convertase of the alternative pathway? a) C4bC2b b) C3bBb c) C3b₂Bb d) C4bC2bC3b

b

Q21. What is the C3 convertase of the lectin and classical pathways? a) C3bBb b) C4bC2b c) C3b₂Bb d) C1qC1rC1s

b

Q22. Which pathway functions in the absence of infection? a) Lectin pathway b) Classical pathway c) Alternative pathway d) All of the above

c

Q23. Do the lectin and classical pathways produce the same C3 convertase? a) Yes, both produce C4bC2b b) No, lectin produces C3bBb and classical produces C4bC2b c) No, lectin produces C4bC2b and classical produces C3bBb d) Yes, both produce C3bBb

a

Q24. Which pathway is first to act? a) Classical b) Lectin c) Alternative d) All act at the same time

c

Q25. Which pathway is second to act? a) Classical b) Lectin c) Alternative d) None of the above

b

Q26. Which pathway is third to act? a) Classical b) Lectin c) Alternative d) None of the above

a