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heart
muscular cone-shaped organ the size of a fist, located behind the sternum and between the lungs. The pumping action of the heart circulates blood throughout the body. The heart consists of two upper chambers, the right atrium and the left atrium, and two lower chambers, the right ventricle and the left ventricle. The atria receive blood returning from the body through the veins. The ventricles pump blood through the arteries from the heart back to the body tissue. The atrial septum separates the atria and the ventricular septum separates the ventricles. The tricuspid and the mitral valves are referred to as the atrioventricular valves. Valves of the heart keep the blood flowing in one direction
bleeding profile
series of tests that measure the ability of various features in the blood to form a clot
tricuspid valve
located between the right atrium and the right ventricle
mitral valve
located between the left atrium and left ventricle
semilunar valves
pulmonary and aortic valves located between the right ventricle and the pulmonary artery and between the left ventricle and the aorta
pericardium
two-layer sac consisting of an external fibrous and an internal serous layer. The serous layer secretes a fluid that facilitates movement of the heart. This layer also covers the heart and is called the epicardium
epicardium
layer that covers the heart
myocardium
middle, thick, muscular layer
endocardium
inner lining of the heart
blood vessels
tubelike structures that carry blood throughout the body
arteries
blood vessels that carry blood away from the heart. All arteries, with the exception of the pulmonary artery, carry oxygen and other nutrients from the heart to the body cells. The pulmonary artery, in contrast, carries carbon dioxide and other waste products from the heart to the lungs
arterioles
smallest arteries
aorta
largest artery in the body, originating at the left ventricle and descending through the thorax and abdomen
veins
blood vessels that carry blood back to the heart. All veins, with the exception of the pulmonary veins, carry blood containing carbon dioxide and other waste products. The pulmonary veins carry oxygenated blood from the lungs to the heart
venules
smallest veins
venae cavae
largest veins in the body. The inferior vena cava carries blood to the heart from the body parts below the diaphragm, and the superior vena cava returns the blood to the heart from the upper part of the body
capillaries
microscopic blood vessels that connect arterioles with venules. Materials are passed between the blood and tissue through the capillary walls
blood
composed of plasma and formed elements, such as erythrocytes, leukocytes, and thrombocytes
plasma
clear, straw-colored, liquid portion of blood in which cells are suspended. Plasma is approximately 90% water and comprises approximately 55% of the total blood vollume
erythrocytes
red blood cells that carry oxygen. Erythrocytes develop in bone marrow
platelets
one of the formed elements in the blood that is responsible for aiding in the clothing process
serum
clear, watery fluid portion of the blood that remains after a clot has formed
lymph
transparent, colorless, tissue fluid that, on entering the lymphatic system, is called lymph. Lymph contains lymphocytes and monocytes and flows in a one-way direction to the heart. Lymph is similar to blood plasma
lymphatic vessels
similar to veins, lymphatic vessels transport lymph from body tissues to the chest, where it enters the cardiovascular system. The vessels begin as capillaries spread throughout the body then merge into larger tubes that eventually become ducts in the chest. They provide a one-way flow for lymph gathered from the tissues to ducts in the chest, where lymph enters through veins into the circulatory system
lymph nodes
small, spherical bodies composed of lymphoid tissue. They may be singular or grouped together along the path of the lymph vessels. The nodes filter lymph to keep substances such as bacteria and other foreign agents from entering the blood. They also produce lymphocytes
spleen
located in the left side of the abdominal cavity between the stomach and the diaphragm. In adulthood, the spleen is the largest lymphatic organ in the body. Blood, rather than lymph, flows through the spleen. Blood is cleansed of microorganisms in the spleen. The spleen stores blood and destroys worn out red blood cells
thymus gland
one of the primary lymphatic organs, it is located anterior to the ascending aorta and posterior to the sternum between the lungs. It plays an important role in the development of the body's immune system, particularly from infancy to puberty. Around puberty the thymus gland atrophies so that most of the gland is connective tissue
multiple myeloma
tumors of the bone marrow
acute coronary syndrome
sudden symptoms of insufficient blood supply to the heart indicating unstable angina or acute myocardial infarction
aneurysm
ballooning of a weakened portion of an arterial wall
angina pectoris
chest pain, which may radiate to the left arm and jar, that occurs when there is an insufficient supply of blood to the heart muscle
arrhythmia
any disturbance or abnormality in the heart's normal rhythmic pattern
artial fibrillation
a cardiac arrhythmia characterized by chaotic, rapid electrical impulses in the atria. The atria quiver instead of contracting, causing irregular ventricular response and the ejection of a reduced amount of blood. The blood that remains in the atria becomes static, increasing the risk of clot formation, which may lead to a stroke.
cardiac arrest
sudden cessation of cardiac output and effective circulation, which requires cardiopulmonary resuscitation
cardiac tamponade
acute compression of the heart caused by fluid accumulation in the pericardial vacity
coarctation of the aorta
congenital cardiac condition characterized by a narrowing of the aorta
congenital heart disease
heart abnormality present at birth
congestive heart failure
inability of the heart to pump enough blood through the body to supply the tissues and organs with nutrients and oxygen
coronary artery disease
a condition that reduces the flow of blood through the coronary arteries to the myocardium, denying the myocardial tissue of sufficient oxygen and nutrients to function fully; most often caused by coronary atherosclerosis
deep vein thrombosis
condition of thrombus in a deep vein of the body. Most often occurs in the lower extremities. A clot can break off and travel to he lungs, causing a pulmonary embolism
hypertensive heart disease
disorder of the heart brought about by persistent high blood pressure
intermittent claudication
pain and discomfort in calf muscles while walking; a condition seen occlusive artery disease
mitral valve stenosis
a narrowing of the mitral valve from scarring, usually caused by episodes of rheumatic fever
myocardial infarction
death (necrosis) of a portion of the myocardium caused by lack of oxygen resulting from an interrupted blood supply
peripheral arterial disease
disease of the arteries, other than those of the heart and brain, that affects blood circulation, such as atherosclerosis and Raynaud disease. The most common symptom of peripheral atherosclerosis is intermittent claudication
rheumatic heart disease
damage to the heart muscle or heart valves caused by one or more episodes of rheumatic fever
varicose veins
distended or tortuous veins usually found in the lower extremities
Hodgkin disease
malignant disorder of the lymphatic tissue characterized by progressive enlargement of the lymph nodes, usually beginning in the cervical nodes
infectious mononucleosis
an acute infection caused by the Epstein-Bar virus characterized by swollen lymph nodes, sore throat, fatigue, and fever. The disease affects mostly young people and is usually transmitted by saliva
atrial fibrillation ablation
a procedure in which abnormal cells that trigger atrial fibrillation are destroyed by using radiofrequency energy
cardiac pacemaker
battery-powered apparatus implanted under the skin with leads placed on the heart or in the chamber of the heart
coronary artery bypass graft
surgical technique to bring a new blood supply to heart muscle by detouring around blocked arteries
coronary stent
a supportive scaffold device implanted in the coronary artery; used to prevent closure of the artery after angioplasty or atherectomy
femoroopopliteal bypass
surgery to establish an alternate route from femoral artery to popliteal artery to bypass an obstruction
intracoronary thrombolytic therapy
an injection of an intravenous dedication to dissolve blood clots in coronary (blood) vessels
percutaneous transluminal coronary angioplasty
procedure in which a balloon is passed through a blood vessel into a coronary artery to the area where plaque is formed. Inflation of the balloon compresses the plaque against the vessel wall, expanding the inner diameter of the blood vessel, which allows the blood to circulate more freely
bone marrow aspiration
a syringe is used to aspirate a sample of the liquid portion of the bone marrow, usually from the ilium for study; used to diagnose, stage, and monitor disease and condition of the blood cells
bone marrow biopsy
a needle puncture to obtain a sample of bone marrow, usually from the ilium, for study; used to diagnose, stage, and monitor disease and condition of the blood cells
bone marrow transplant
infusion of normal bone marrow cells from a donor with matching cells and tissue to a recipient with a certain type of leukemia or anemia
digital subtraction angiography
a process of digital radiographic imaging of the blood vessels that "subtracts" or removes structures not being studied
Doppler ultrasound
a study that uses sound for detection of blood flow within the vessels; used to assess intermittent claudication, deep vein thrombosis, and other blood flow abnormalities
exercise stress test
a study that evaluates cardiac function during physical stress by riding a bike or walking on a treadmill. Electrocardiography, echocardiography, and nuclear medicine scanning are three types of tests performed to measure cardiac function while exercising. Echocardiography is fast becoming the preferred choice of testing over electrocradiography
single-photon emission computed tomography
a nuclear medicine scan that visualizes the heart from several different angles. A tracer substance such as sestamibi or thallium is injected intravenously. The SPECT scanner creates images from the tracer absorbed by the body tissues. It is used to assess damage to cardiac tissue
thallium test
a nuclear medicine test used to diagnose coronary artery disease and assess revascularization after coronary artery bypass surgery. Thallium, a radioactive isotope, is injected into the body intravenously; a radiation detector is placed over the heart and images are recorded. Thallium is taken up by the normal myocardial cells, but not in ischemia or infarction. These areas are identified as cold "spots" on the images produced. Thallium testing can be performed when the patient is at rest or it can be part of a stress test
transesophageal echocardiogram
an ultrasound test that examines cardiac function and structure by using an ultrasound probe placed in the esophagus, which provides views of the heart structures
cardiac catherterization
an examination to determine to condition of the heart and surrounding blood vessels. Acatheter is passed into the heart through blood vessel and is used to record pressures and inject a contrast medium, enabling the visualization of the coronary arteries, great vessels, and the heart chambers; used most frequently to evaluate chest pain and coronary arter y disease
impedance plethysmography
measures venous flow of the extremities with a plethysmograph to detect clots by measuring changes in blood volume and resistance (impedance) in the vein; used to detect deep vein thrombosis
auscultation
hearing sounds within the body through a stethoscope
blood pressure
pressure exerted by the blood against the blood vessel walls. A blood pressure measurement written as systolic pressure (120) and diastolic pressure (80) is commonly recorded as 120/80
percussion
tapping of a body surface with the fingers to determine the density of the part beneath
pulse
the number of times per minute the heartbeat is felt on the arterial wall. The pulse rate is most commonly felt over the radial artery; however, the pulsations can be felt over a number of sites, including the femoral and carotid arteries
sphygmomanometer
device used for measuring blood pressure
stethoscope
an instrument used to hear internal body sounds; used for performing auscultation and blood pressure measurement
C-reactive protein
a blood test to measure the amount of C-reactive protein in the blood, which, when elevated, indicates inflammation in the body. It is sometimes used in assessing the risk of cardiovascular disease
creatine phosphokinase
a blood test used to measure the level of creatine phophokinase, an enzyme of heart and skeletal muscle released into the blood after muscle injury or necrosis. The test is useful in evaluating patients with acute myocardial infarction
homocysteine
a blood test used to measure the amount of homocysteine in the blood. Homocysteine is an amino acid that, if elevated, may indicate an increases risk of cardiovascular disease
lipid profile
a blood test used to measure the amount of lipids in a sample of blood. This test is used to evaluate the risk of developing cardiovascular disease and to monitor therapy of existing disease. Results provide levels of total cholesterol, high-density liporotein, low-density lipoprotein, very-low-density lipoprotein, and triglycerides
troponin
a blood test that measures troponin, a heart muscle enzyme. Troponins are released into the blood approximately 3 hours after necrosis of the heart muscle and may remain elevated from 7 to 10 days. The test is useful in the diagnosis of a myocardial infarction
coagulation time
blood test to determine the time it takes for blood to form a clot
complete blood count and differential count
basic blood screening that measures hemoglobin, hematocrit, red blood cell number and morphology, leukocyte count, and white blood cell differential and platelet count. This test is automated, thus done easily and rapidly, and provides a tremendous amount of information about the blood
hematocrit
a blood test to measure the volume and number of red blood cells. It is used in the diagnosis and evaluation of anemic patients
hemoglobin
blood test used to determine the concentration of oxygen-carrying components (hemoglobin) in red blood cells
prothrombin time
blood test used to determine certain coagulation activity defects and to monitor anticoagulation therapy for patients taking Coumadin, an oral anticoagulant medication.
atrioventricular
pertaining to the atrium and ventricle
cardiac
pertaining to the heart
hematopoiesis
formation of blood (cells)
hemostasis
stoppage of bleeding
cardiopulmonary resuscitation
emergency procedure consisting of artificial ventilation and external cardiac meassage
defibrillation
application of an electric shock to the myocardium through the chest wall to restore normal cardiac rhythm
diastole
phase in the cardiac cycle in which the ventricles relax between contractions (diastolic is the lower number of a blood pressure reading)
extracorporeal
occurring outside the body. During open-heart surgery extracorporeal circulation occurs when blood is diverted outside the body to a heart-lung machine
extravasation
escape of blood from the blood vessel into the tissue
fibrillation
rapid, quivering, noncoordinated contractions of the atria and ventricles
heart murmur
a short-duration humming sound of cardiac or vascular origin
hypertension
blood pressure that is above normal (greater than 140/90)
hypertriglyceridemia
excessive amount of triglycerides in the blood; associated with an increased risk of cardiovascular disease
hypotention
blood pressure that is below normal (less than 90/60)
lipids
fats and fatlike substances that serve as a source of in the body and are an important constituent of cell structure
lumen
space within a tubular part or organ, such as the space within a blood vessel
vasoconstrictor
agent or nerve that narrows the blood vessels