SHUNTS Hematology CH6

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Last updated 12:26 AM on 9/24/26
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10 Terms

1
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What are the 3 glycolysis diversion pathways (SHUNTS)?

  1. HMP

  2. Methemoglobin reductase pathway

  3. Rapport-Luebering pathway

These shunts are going to function to keep the RBC in balance


2
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Do shunts produce ATP?

NO shunts do not produce ATP

3
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What is the HMP pathway?

Hexose Monophosphate Pathway

4
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Which enzyme is important in HMP?

G6PD

5
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What happens in G6PD DEFICIENCY?

RBCs are vulnerable to oxidative damage

6
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What is Methemoglobin?

BAD hemoglobin has Fe3+ instead of Fe2+ which PREVENTS oxygen BINDING

7
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What does the Methemoglobin reductase pathway do?

REDUCE Methemoglobin using NADPH

Fe3+ → Fe2+

8
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What is the Rapport-Luebering Pathway

Generates the 2,3-BPG

9
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What does 2,3-BPG do?

Stimulates increased OXYGEN release

10
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What is the overall function of the SHUNTS?

Stabilize the RBC