Cancer Bio

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9 Terms

1
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Why is cancer termed a wound that does not heal?

2
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What are the 14 hallmarks of cancer?

3
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Why are the hallmarks of cancer so relevant to cancer biology?

4
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Describe a role for p53 in one of the hallmarks of cancer

Most cancers have lost or mutated p53


p52 = guardian of the genome; tumor suppressor

In normal cells, if there is DNA damage, p53 is recruited (on)/split from mdm2

p53 causes cell cycle arrest or apoptosis if DNA is too damaged

5
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Describe a role for autophage in one of the hallmarks of cancer

6
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Describe a role for autocrine signalling in one of the hallmarks of cancer

7
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Describe a role for paracrine signalling in one of the hallmarks of cancer

8
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Describe a role for telomerase in the hallmarks of cancer

9
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Why is the tumor microenvironment important in cancer development?