CellCycle

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Last updated 2:14 AM on 4/24/26
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4 Terms

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Quinescent

Ability to go from G0 to G1

Example = Mammary gland (puberty) in g0 till puberty then g1

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Steroid vs Peptide Hormones

Steroid Hormone can diffuse into cell crossing plasma membrane, don’t need a messenger can signal themselves as a transcription factor. Hydrophobic.

Peptide Hormone can’t cross membrane, binds to plasma membrane receptor, uses 2nd messenger.

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Estrogen - Nuclear Hormone Receptor

Estrogen binds to Estrogen Receptor, ER dimerizes and creates an estrogen response element alongside coactivators, growth factor.

ER = Nuclear Hormone Receptor, DNA Binding Domain is a Zinc Finger

Tamoxifen competes with estrogen to bind ER, prevents dimerization.

Overactivation of ER correlated with breast cancer.

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Study rest w/ Diagram