Enzyme inhibition

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4 Terms

1
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What are inhibitors?

Substances that directly/indirectly interfere with functioning of active site & therefore reduces activity

2
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Describe competitive inhibitors

Competitive inhibitor = a substance with a SIMILAR shape to the substrate and a

complementary shape to the enzyme's active site.

‣ Competes for and binds to the active site.

‣ Fewer enzyme-substrate complexes form.

‣ Can be overcome by increasing the substrate concentration.


3
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Describe non-competitive inhibitors

Non-competitive inhibitor = a substance that binds to allosteric site

‣ Causes the active site to change shape.

‣ Substrate can no longer bind to active site.

‣ Fewer enzyme-substrate complexes form.

‣ Decreases the rate of reaction.

‣ CANNOT be overcome by increasing substrate concentration.


4
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2 types of enzyme inhibitors

Competitive & non-competitive