Looks like no one added any tags here yet for you.
List the Choline esters (Direct muscarinic agonists)
Bethanechol
Carbachol
Bethanechol
Activates muscarinic receptors
Uses: Atony
Carbachol
Muscarinic and Nicotinic activator
Uses: Topically for glaucoma
List the Non-Choline esters (Direct muscarinic agonists)
Pilocarpine, muscarine, cevimeline
Pilocarpine
Activates muscarinic receptor
Uses: Sjorgen syndrome, Acute glaucoma
may cause vascosintriction
muscarine
Activates muscarinic receptor
Uses: Mushrooms
cevimeline
M3 selective muscarinic receptor
Uses: Sjogren syndrome
List the Nicotinic Agonists
Nicotine
Varenicline
Nicotine
Activates N receptors, opens NA+ K+ channels
Uses: Smoking cessation
Side effects: hypertension, nausea, vomiting, diarrhea, tachycardia
Varenicline
Partial N agonist
Uses: Smoking cessation
Side effects: hypertension, sweat, diarrhea, polyuria, sensory disturbance
List the Alcohol Anticholinesterase drugs
Edrophonium
Edrophonium
Inhibits AchE and amplifies Ach
Uses: Reverse Nm blockade post surgery
Diagnose myasthenia gravis
Side effects: increases para effects, nausea, vomiting, diarrhea
List the carbamates Anticholinesterase drugs
Neostigmine
Pyridostigmine
Physostigmine
Neostigmine
Inhibits AchE and amplifies Ach, nicotinic agonist
Uses: Reverses Nm blockade, treat myasthenia gravis
Side effects: long duration increases para effects, nausea, vomiting, diarrhea
Pyridostigmine
Inhibits AchE and amplifies Ach
Uses: Treat myasthenia
Side effects: long duration increases para effects, nausea, vomiting, diarrhea
Physostigmine
Inhibits AchE and amplifies Ach
Uses: reverse atropine poison, acute glaucoma topical
Side effects: long duration increases para effects, nausea, vomiting, diarrhea + seizures
List the Anticholinesterase drugs for alzheimer’s
Donepezil, Rivastigmine, Galantamine, Tacrine
Donepezil, Rivastigmine, Galantamine, Tacrine
Cholinesterase inhibitors
Uses: Alzheimer’s
Side effects: Nausea, vomiting
*Tacrine is not used anymore due to hepatotoxicity
List the organophosphate Anticholinesterase drugs
Parathion
Malathion
Sarin, tabun
Echothiopate
Parathion
Inhibits AchE and amplifies Ach
Uses: insecticide that lasts says to weeks
Lethal
Malathion
Inhibits AchE and amplifies Ach
Uses: insecticide that lasts days
Not as lethal as parathion
Sarin, Tabun
Inhibits AchE and amplifies Ach
Uses: Terrorist gas
Lethal
Echothipate
Inhibits AchE and amplifies Ach
Uses: FORMERLY for glaucoma
Motion Sickness Muscarinic Antagonists
Scopolamine
GI Disorder Muscarinic Antagonists
Dicyclomine
Glycopyrrolate
Long acting Ophthalmology Muscarinic Antagonists
Atropine
Scopolamine
Short acting Ophthalmology Muscarinic Antagonists
Tropicamide
Cyclopentolate
Homatropine
Respiratory Muscarinic Antagonists
Ipratropium, Tiotropium, Aclidinium, Umeclidinium
Urinary Muscarinic Antagonists
Oxybutynin , Darifenacin, Solifenacin, Tolteridone, Fesoterodine, Trospium(Less CNS affect)
Cholinergic Poisoning Muscarinic Antagonists
Atropine
2PAM (Pralidoxime)
Scopolamine
Uses: Motion Sickness
Toxicity: tachycardia, blurred vision, delirium, drowsiness, amnesia, dry mouth
Dicyclomine, Glycopyrrolate
MOA: competitive antagonist at M3 receptors
Uses: IBS, minor diarrhea
Toxicity: Tachycardia, confusion, urinary retention, increased intraocular pressure, constipation
Atropine, Homatropine, Cyclopentolate, Tropicamide
MOA: Competitive antagonist @ all M receptors
Uses: Eye exam
Toxicity: acute closed angle glaucoma
Ipratropium, Tiotropium, Aclidinium, Umeclidinium
MOA: competitive nonselective antagonist @ all M receptors
Uses: COPD, Asthma (acute)
Toxicity: dry mouth, cough
shortest dur: Ipratropium
Oxybutynin , Darifenacin, Solifenacin, Tolteridone, Fesoterodine,Trospium(Less CNS affect)
MOA: slight M3 selective muscarinic antagonist
Uses: Urge incontinence
Toxicity: tachycardia, constipation, increased intraocular pressure, dry mouth, aggravate BPH
*Trospium—>Less CNS affect
Atropine
MOA: non selective competitive antagonist @ all M receptors in CNS and periphery
Use: antidote for cholinesterase poisoning & mushroom poisoning
Pralidoxime (2PAM)
MOA: AchE regenerator
Use: antidote for ach poisoning, must use early
Toxicity: Muscle weakness
List the Short Acting Nondepolarizing NMJ Blockers
Mivacurium
List the Intermediate acting Non depolarizing NMJ Blockers
Atracurium, Cisatracurium, Rocuronium, Vecuronium
List the Long acting Non depolarizing NMJ Blockers
Pancuronium, pipecuronium, D-Tubocurarine
List the Depolarizing short acting NMJs
Succinylcholine
Sugammadex
Can reverse rocuronium & vecuronium
Uses for NMJ Blockers
Surgical Relaxation
Endotracheal intubation
Control of ventilation
Treat convulsions