Anesthetic Agents & Adjuncts

Anesthetic Agent vs. Adjunct

Ways to Classify Anesthetic Drugs

Receptor Interactions – general concepts

Example:  Opioid Receptors

“Key and Lock” = Drug and Receptor

Analgesia?

Mixing Drugs

Controlled Substances

Preanesthetics – drug classes used

ANTICHOLINERGICS - block PSNS

(i.e. block salivation, block low HR)

ANTICHOLINERGICS  = “Parasympatholytics”

PHENOTHIAZINES - no analgesia

BENZODIAZEPINES C- No true analgesia

ALPHA2 AGONISTS

OPIOIDS C (aka narcotics)– reversed with naloxone

OPIOIDS – fun facts

“NEUROLEPTANALGESIA”

PROPOFOL - no analgesia

ALFAXALONE C- No analgesia

ETOMIDATE - uncommon, expensive and many adverse effects  - No analgesia

BARBITURATES C - No analgesia

CYCLOHEXAMINE DISSOCIATIVES C

KETAMINE – fun facts

GUAIFENESIN - compounded

HALOGENATED INHALANTS - No analgesia

Major effects of iso and sevo

MAC (Minimum Alveolar Concentration)

ISOFLURANE - No analgesia

SEVOFLURANE - No analgesia

NITROUS OXIDE

NITROUS OXIDE - risks

GENERAL ANESTHESIA….