ABNORMAL RESULTS OF STUDIES

Dereubeis

(ADM – Anti-depressant Medication, CT – cognitive therapy) Remission rates were 46% in the ADM cell vs 40% in the CT cell. Over the 16-week treatment course, attrition rate was 16% for the ADM cell and 15% for CT. Attrition did not differ significantly between sites or across conditions after 8 weeks or after 16 weeks

Hollon

76% of the patients who had received drug treatment relapsed following medication withdrawal, compared with only 31% of the patients who had been treated with therapy.  

Griner and Smith

Culturally adapted interventions were 4x more effective than non-adapted strategies. Interventions in the client’s native language 2x effective than ones in English

Naeem

Four main themes: Patient perspectives of how MDD affected their lives; How their MDD was caused; How they received treatment/help; Knowledge and experience around treatment for MDD. More emphasis on biological treatments over therapy. Most patients presented somatic symptoms.

March et al

response rates: Week 12 = 73% for combination therapy, 62% for fluoxetine therapy, and 48% for CBT. Week 18 = 85% for combination therapy, 69% for fluoxetine therapy, and 65% for CBT. Week 36 = 86% for combination therapy, 81% for fluoxetine therapy, and 81% for CBT. Suicidal ideation decreased with treatment, but less so with fluoxetine therapy than with combination therapy or CBT.