Innate-Complement & Antimicrobial Factors

Proteins synthesized from virus-infected cells to prevent nearby cell infection

Interferons

Proteins produced by neighboring interferons in a healthy cell to block viral receptors

TIP (Translation Inhibitory Protein)

A specific interferon important in tuberculosis diagnosis

Interferon Gamma

A system of at least 20 plasma proteins that circulate until activated

Complement

Complement activated via antibodies

Classical Pathway

Complement activated via water-soluble proteins that bind to sugars on microorganism surfaces

Lectin Pathway

Spontaneous activation of complement (C3) in response to no inhibitors on a cell surface

Alternative pathway

The binding of C3b-C9 proteins to a cell surface, opening up holes and lysing the target

MAC (Membrane Attack Complex)

Coating a cell’s surface with C3b proteins to allow easier binding by other immune cells (also done by antibodies)

Opsonization

Endogenous fever inducing chemical, released by leukocytes and macrophages

Pyrogens

Exogenous fever are caused by

Pathogens and Superantigens