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Plasma

Blood platelets and white blood cells

Erythrocytes

Produced in the bone marrow

Pluripotent stem cell

Erythroblasts

Reticulocyte

Erythrocyte

Present in the blood

Fe2+

Bilirubin

Amino acids

Fe2+ for production of erythrocytes

Fe2+ stored as ferritin

Bilirubin excreted in bile

Pluripotent stem cell

Megakaryocyte

Basophil

Neutrophil

Eosinophil

Monocyte

Lymphocyte

Blood platelets

Polymorphonuclear granulocytes

Adhesiveness of blood platelets

Blood platelets

Thromboxane A2

ADP

•
Collagen

Adhesiveness of blood platelets

Prostacyclin

Normal endothelium

Blood platelets

Injured endothelium

Contraction of injured blood vessel

Formation of platelet plug

Clot formation

Hemostasis

Fibrinogen

Thrombin

Loose meshwork of fibrin

Factor XIII inact

Factor XIII act

Stabilized meshwork of fibrin

O2

Heme

Fe2+

Intrinsic pathway

Extrinsic pathway

Factor X act

Factor X inact

Prothrombin

Thrombin

Fibrinogen

Fibrin

Plasminogen activator

Plasminogen

Plasmin

Fibrin

Degradation products of fibrin