- most common in middle-aged women
- due to repetitive wrist motion, gripping, pinching
- predisposed: pregnancy, oral contraceptives, kidney dysfunction
- insidious onset
- paresthesia in palm, thumb and fingers 2 +3
- night burning
- aggravated ADLs
- altered sensation
- (+) Phalen's test, (+) hand elevation test, (+) EMG/NCV tests
- if chronic: atrophy of thenar eminence and weakness of muscles supplied by median n