Pharmacology Lecture 12: NSAIDs

What is the prototype drug for NSAIDs?

Ibuprofen (Motrin)

What is the main benefit of using NSAIDs over Tylenol and Aspirin?

Anti inflammatory effect

Are NSAIDs or narcotic codeine more effective against dental pain?

NSAIDs

Are NSAIDs available without prescription?

Yes

What are the enzymes that drive inflammation?

Cyclooxygenases 1 & 2 (COX1 + COX2)

What are the three pharmacological actions of NSAIDs?

1. Anti-inflammatory

2. Analgesic

3. Antipyretic

Is NSAIDs or aspirin a safter alternative?

NSAIDs

How do NSAIDs reduce inflammation and pain?

Reversibly inhibiting COX-1 and COX-2 enzymes

What formation is decreased by NSAIDs action?

Prostaglandin precursors

What is the main adverse effect of NSAIDs?

Abdominal pain/ulcer

How can ibuprofen prolong blood clotting?

Preventing platelet aggregation

How does NSAIDs decrease lithium excretion for the kidney?

Inhibiting the prostaglandin process

What adverse effect of NSAIDs could cause slurred speech and mental confusion?

Lithium toxicity

Patients with what allergy should not take NSAIDs?

Aspirin

What are the two OTC brands for NSAIDs?

1. Advil

2. Aleve

Is NSAIDs used to treat rheumatoid arthritis?

No

What is reduced when inhibiting COX-2?

Pain

What is the only COX-2 inhibitor presently available?

Celecoxib

Why was Vioxx removed from the market as a COX-2 inhibitor?

Increased risk of heart attacks

What is mainly inhibited by Celecoxib?

Synthesis of prostaglandins

What does NSAIDs causing unopposed vasoconstriction in the renal system lead to?

Renal insufficiency