DNA L14 (Replication)

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5 Terms

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Semi-conservative replication

happening in S phase

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Initiation

Occurs at origin of replication

Double helix must be unwound

  • DNA helicase

RNA primer added

  • short piece of RNA

  • made by Primase

  • required to start adding new DNA nucleotides

  • later removed, replaced with DNA


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Elongation

DNA is read in 3’ to 5’ direction

DNA synthesized from 5’ to 3’

DNA polymerase adds nucleoside triphosphate

Forms new phosphodiester bond

Happens at replication fork

2 different processes

  • leading strand synthesis- 5’ to 3’ towards replication fork

  • lagging strand synthesis- synthesis 5’ to 3’ away from replication fork

    • elongates in short, discontinuous segments Okazaki fragments

      • connected via ligase activity


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Leading strand synthesis

5’ to 3’ towards replication fork

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Lagging strand synthesis

synthesis 5’ to 3’ away from replication fork

  • elongates in short, discontinuous segments Okazaki fragments

    • connected via ligase activity