Pathology l8

Granuloma

Granuloma

Start as chronic specific inflammation

Mycobacterium

Presenting infection By microorganisms That are difficult to eradicate example

Rheumatoid, arthritis and multi sclerosis

Immune mediated, inflammatory disease example

Inflammatory bowel disease

unregulated immune responses against microbes

Bronchial asthma

Unregulated immune response against common environmental substances

Silica

Prolonged exposure to, potentially toxic agents exogenous as

Silicosis

Silica Result in an inflammatory lung disease called

Macrophages/lymphocytes /plasma cells

mononuclear cells

Angiogenesis /fibrosis

Attempts at healing by connective tissue accomplished by

Angiogenesis

proliferation of small, blood vessels

Blood monocytes

Macrophages derived from

Phagocytosis

macrophages function

Antigen presenting cell

Macrophage function

Cytokine release

Macrophages Function

Synthesis cytokines, complement, , components, blood clotting factors, proteases

Macrophages function

Dendritic cells

Professional antigen presenting cells that trigger immune responses to antigens