B lactam antibiotics

Penicillin that causes psuedomembranos colitis and C/I in EBV infections?

Ampicillin

It is excreted more through bile.

Ampicillin is doc for?

Listeria meningitis and enterococcal endocarditis

Ampicillin with Gentamicin is given.

More effective against H.Influenze and Salmonella

Ceftriaxone-3rd generation

Penicillinase resistant penicillin is used for?(PRP)

Gram positive,Staph.aurues

MRSA and mx

Due to transpeptidase mutation-MEC 2A gene mutation.

Doc:Vancomycin IV

VRSA doc?

Daptomycin

In pneumonia-Linezolid.

Enterobacteria resistance is due to?

G-negative (SPEKS)

And how to manage?

ESBL-Extended spectrum B lactamase enzyme

Add B lactamase inhibitors with extended spectrum or 3rd gen cephalosporins.

Resistance to B lactamase inhibitors

Doc:Carbapenem

If also resistant,doc:Colistin.

Doc for surgical prophylaxis

1st gen cephalosporins-Cefazolin Iv/IM

Effective against MSSA and streptococci

Gram positive infections

Cephalosporins are ineffective in which infection?

Listeria monocytogenes-listeriosis-naturally resistant to cephalosporins.

Cephalosporins w strong anti-psudeomonal activity

1-CEFTAZIDIME:3rd gen-strong,suitable for diabetic foot ulcer and HAPI

2-CeFoperazone-3rd gen

3-Cefepime:4th gen

4-Ceftolozanw:5gen

Cephalosporin that doesn’t require dose adjustment in renal failure?

1-Ceftriaxone:3rd gen,dual excretion

2-Cefoperazone-3rd gen,biliary excreTion

3-Cefpiramide-3rd gen,biliary

Doc for bacteriodes

2nd gen

Best for anaerobes

Doc for gram negative community aquired?

3rd gen cephalosporins

Antibiotics causing CDI

1-Clindamycin

2-3rd gen cephalosporins

3-Ampicillin

4-Fq

Daptomycin

Cell membrane inhibitor,bactericidal

Used for resistant gram positive infections-VRsA,VRE

Not effective in pneumonia.

Colistin

Cell membrane inhibitor,bactericidal

Other names:POLYMIXIN E,COLISTIMETHATE

Reserved for gram negative infections like carbapenem resistant cases.

Colistin is ineffective against?

Burkholderia

Serratia

Proteus

Imipenem combined with cilastatin?

Imipenem converted to toxic form by DHP-1 enzyme in kidney.

Cilastatin is DHP-1 inhibitor.

Iv clindamycin in TSS?

To reduce toxin production

Vanco-kills bacteria.

Red man syndrome?

Side effect of vancomycin due to release of histamine when it’s rapidly given as IV

Mx:Give slow IV infusion of vancomycin

Doc in Hospital aquired infections like VAP

Carbapenem

Imipenem w cilastatin