morp RBC part 1 size,

As an RBC matures, what changes happens

Nucleated → non-nucleated.

It gets smaller in size

color changes to Reddish

turns Red, is 7–8, with 2–3 pallor, and has Glycophorin + Spectrin.”

what is A normal RBC is size approximately:

7-8 um with 2-3 um central pallor

Normal RBC size variation is approximately:
A. 1%
B. 5%
C. 25%
D. 50%

B. 5%

Which two are RBC membrane proteins from your notes?
A. Albumin and fibrinogen
B. Glycophorin and spectrin
C. Hemoglobin and ferritin
D. Actin and myosin

B. Glycophorin and spectrin

Macrocytosis is defined as an MCV

A. <80 fL
B. 80–100 fL
C. >100 fL
D. >150 fL

C. >100 fL

Why RBC macrocytosis (larger)

Impaired DNA synthesis → fewer cell divisions → BIG cells

Increased erythropoiesis → premature release of reticulocytes : reticulocytes, diffusely basophilic erythrocytes ( they young and big)

Increased membrane cholesterol and lecithin ( cholesterol, lecithin)

When you see MACROCYTES you ask your self?

SHAPE? COLOR? PALLOR? INCLUSIONS? CAUSE?”

Oval or round → Red or blue → Pallor → Inclusions → Pathologic reason

microcytes can be caused by problems with:

Iron absorption ( body not absorbing enough iron)

Iron release( iron is not properly releases)

Iron utilization( have iron but isn’t properly used)

Microcytosis is associated with an MCV:

A. <80 fL
B. 80–100 fL
C. >100 fL
D. >120 fL

A. <80 fL

. Defective hemoglobin synthesis causes RBCs to undergo:

A. Fewer divisions
B. More divisions
C. No divisions
D. Nuclear division only

B. More divisions

A defective hemoglobin synthesis problem typically produces what blood picture?

A. Macrocytic, hyperchromic
B. Normocytic, normochromic
C. Microcytic, hypochromic
D. Macrocytic, hypochromic

C — Microcytic, hypochromic

Which can contribute to microcytes according to your notes?

A. Defective iron absorption
B. Increased DNA synthesis
C. Increased cell size
D. Increased RBC membrane cholesterol

A. Defective iron absorption

what cause microcytes

Decreased or defective globin synthesis.

Which is a possible pathology cause of microcytes?

Iron deficiency- not enough iron- low hgb production

Thalassemic conditions- abnormal globin/hgb production

Sideroblastic anemia- problem using iron to make hgb

Lead poisoning- interferes with hgb production

A hypochromic RBC has central pallor:

A. <1 µm
B. 1–2 µm
C. 2–3 µm
D. >3 µm

D. >3 µm

Which RBC index is used to judge hypochromia?

A. MCV
B. MCH
C. MCHC
D. RDW

C. MCHC

A low MCHC indicates:

A. Macrocytosis
B. Hypochromia
C. Poikilocytosis
D. Leukocytosis

B. Hypochromia

Which condition is associated with hypochromia in your notes?

A. Iron-deficiency anemia
B. Leukemia
C. Polycythemia
D. Thrombocytopenia

A — Iron-deficiency anemia

Sideroblastic anemia can show what type of blood picture according to your notes?

A. Only normocytic
B. Only microcytic
C. Dimorphic
D. Only macrocytic

C. Dimorphic

Which combination of RBC sizes can be seen in the sideroblastic anemia blood picture from your notes?

A. Only microcytes
B. Only macrocytes
C. Macrocytic, normocytic, and microcytic cells
D. Only normocytes

C. Macrocytic, normocytic, and microcytic cells

Pseudohypochromia means:

A. True decrease in hemoglobin
B. Artificially induced appearance of hypochromia
C. Increased RBC production
D. Increased MCV

B. Artificially induced appearance of hypochromia

What can cause pseudohypochromia according to your notes?

A. Iron deficiency
B. Water artifact
C. Lead poisoning
D. Thalassemia

B. Water artifact

In a water artifact, the central pallor is described as:

A. Completely absent
B. Distinctly outlined
C. Smaller than normal
D. Filled with iron

B. Distinctly outlined

What is used to grade hypochromia?

A. RBC nucleus size
B. Central pallor compared with cell diameter
C. RBC count
D. WBC count

B. Central pallor compared with cell diameter

Polychromasia is caused by RBCs entering the peripheral blood in what state?

A. Overmature
B. Immature
C. Nucleated only
D. Destroyed

B. Immature

What color are polychromatophilic RBCs?

A. Bright red
B. Yellow
C. Gray-blue
D. Green

C — Gray-blue

Polychromatophilic or diffusely basophilic macrocytes are:

A. Neutrophils
B. Platelets
C. Reticulocytes
D. Mature RBCs

C. Reticulocytes

Reticulocytes contain residual:

A. DNA
B. RNA
C. Iron only
D. Calcium

B. RNA

Which type of staining is used to demonstrate reticulocytes?

A. Gram stain
B. Acid-fast stain
C. Supravital stain
D. Wright stain only

C. Supravital stain

Which stain is associated with reticulocyte identification in your notes?

A. Methylene blue
B. Eosin
C. Crystal violet
D. Safranin

A. Methylene blue

RED BLOOD CELL MORPHOLOGY SHAPE VARIATION

•Target  cell

•Helmet cell

•Spherocyte

•Acanthocyte

•Ovalocyte

•Schistocyte

•Stomatocyte

•Teardrop

•Sickle cell

•Burr Cell