NSAIDS + SALICYLATES pharm cards

what is NSAIDS

non-steroidal anti-inflammatory drugs

what is salicylates

aspirin

How do NSAIDs work?

They interfere with the conversion of arachidonic acid to COX-1/COX-2, therefore prostaglandins and thromboxane A2 are not produced, which leads to decreased pain, inflammation, and fever

How do salicylates work?

inhibit prostaglandin synthesis

Prostaglandins

A group of bioactive, hormone-like chemicals derived from fatty acids that have a wide variety of biological effects including roles in inflammation, platelet aggregation, vascular smooth muscle dilation and constriction, cell growth, protection of from acid in the stomach, and many more.

generic meds

ibuprofen

aspirin

ketorolac

who needs this class

pts with mild to moderate pain, inflammation, arthritis, fever

who should not use this med

pts with bleeding disorders, peptic ulcer disease, severe hepatic,, renal, or cardiovascular disease, kidney issues

NSAIDs can cause kidney damage which causes

hearing loss

salicylates cause _____ in kids

reyes syndrome

reyes syndrome

Syndrome which is an acute encephalopathy (inflammation of the brain). Usually follows a viral illness & linked to intake of aspirin. Use acetaminophen (not aspirin) to reduce fever with child with a communicable disease (virus) to prevent this.

side effects of nsaids

nausea

heartburn

dizziness

epigastric pain

gi ulceration

life threatening of nsaids

gi damage

kidney damage which leads to hearing loss

rn implications

assess pain

asses limitations of movement

assess fever

assess gi blood loss

dont give this med to pts with

asthma

take nsaids when

after meals

avoid taking nsaids with

alcohol

remain upright for ______ after taking

15-30

antidote for nsaids is

platelets

children under 19 should not be administered aspirin when they have ___ bc of risk of Reyes syndrome

flu like symptoms

fever

chicken pox

nsaids should be avoided

2nd half of pregnancy

nsaids of no

no immunosuppressive effects