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Empty stomach + nighttime epigastric burning
Duodenal ulcer
Heavy-meal attacks + persistent pain now + high amylase
Gallstone pancreatitis
Fever then jaundice + ALT 3440 + 30 acetaminophen tablets daily
Acute hepatitis with possible acetaminophen toxicity
Old blood transfusion + ascites + low albumin + low platelets
Cirrhosis possibly caused by hepatitis C
Bloody mucoid diarrhea + urgency + repeated attacks
Ulcerative colitis
Older patient + left lower abdominal pain + fever
Diverticulitis
Progressive jaundice + weight loss + itching + pale stools
Pancreatic cancer causing biliary obstruction
Bulky diarrhea + weight loss despite good appetite
Celiac disease
Right upper abdominal pain + positive Murphy sign
Acute cholecystitis
Older patient + changed bowel habit + anemia or weight loss
Colorectal cancer
Heavy alcohol use + thin limbs + ascites
Decompensated alcohol-related liver disease
Malaise and joint aches then jaundice + high liver enzymes
Acute viral hepatitis
Years of bloating and altered stools + pain improves after defecation
Irritable bowel syndrome
Right lower abdominal pain + fever + guarding
Acute appendicitis
Years of swallowing difficulty + undigested food regurgitation + recurrent pneumonia
Achalasia
Recurrent colicky upper abdominal pain + jaundice + dark urine
Obstructive jaundice likely from a common bile duct stone
Woman + itching + cholestatic liver tests + antimitochondrial antibodies
Primary biliary cholangitis
Years of heartburn + solids get stuck + benign distal stricture
GERD with peptic stricture
Brief recurrent yellow eyes + otherwise well + isolated indirect bilirubin elevation
Gilbert syndrome
Recurrent ulcers despite treatment + high fasting gastrin
Zollinger–Ellison syndrome
Severe epigastric pain radiating to back + vomiting + high lipase
Acute pancreatitis
Tender red shin nodules fading like bruises + bowel symptoms
Erythema nodosum associated with Crohn disease
Dark skin + diabetes + liver disease + sexual dysfunction
Hereditary hemochromatosis
Appetite loss + weight loss + persistent epigastric pain + vomiting after meals
Gastric cancer
Relapsing diarrhea + abdominal pain + significant weight loss
Crohn disease
Ascites + enlarged spleen + dilated abdominal wall veins
Cirrhosis with portal hypertension
Previous liver disease + weight loss + hard irregular liver
Hepatocellular carcinoma