Apolipoprotein Table

Chr 11

cofactor for LCAT

Chylomicron, HDL

Apo A-I

location

fxn

lipoprotein carriers

1

inactivate hepatic triglyceride lipase

HDL

Apo A-II

location

fxn

lipoprotein carriers

11

activates LCAT

chylomicron, HDL

Apo A-IV

location

fxn

lipoprotein carriers

Apo-IV

promotes intestinal absorption of lipids

facilitate release of C2

Apo A-I, Apo A-IV, Apo-C-III

chromosome 11

Apo B-100, Apo B-48

chromosome 2

Apo C-I, C-III, E

chromosome 19

Apo A-II

chromosome I

Apo (a)

chromosome 6

2

secretion of trigly from intestine

chylomicron

Apo B-48

location

fxn

lipoprotein carriers

2

secretion of triglyceride from liver binding protein to LDL receptor

IDL, LDL, VLDL

Apo B-100

location

fxn

lipoprotein carriers

Apo B-100

major lipoprotein involve in endogenous pathway

19

activated LCAT, inhibits clearance of chylomicrons

Chylomicron, HDL, VLDL

Apo C-I

location

fxn

lipoprotein carriers

11

cofacter LPL

Chylomicron, HDL, VLDL

Apo C-II

location

fxn

lipoprotein carriers

11

inhibits clearance of chylomicrons

chylomicron, VLDL, HDL, LDL

Apo C-III

location

fxn

lipoprotein carriers

19

facilitates uptake of chylomicron remnants and IDL

Chylomicron, LDL, VLDL, HDL

Apo E

location

fxn

lipoprotein carriers

6

unknown

Lp(a)

Apo (a)

location

fxn

lipoprotein carriers

Apo C-III

stimulate VLDL assembly

inhibit and intefere VLDL and LDL receptor related protein

Apo E-4

related to Alzeimher’s disease

Apo E-$

responsible for statin hyporesponsiveness

Apo E2

type 3 hyperlipoproteinemia

Apo E 3

most frequent allele in general population