Mannich reaction

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Last updated 6:18 AM on 10/11/26
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Mannich reaction

  • Reactants: enolizable carbonyl compound, formaldehyde and a primary or secondary amine.

  • Product: β-amino carbonyl compound.

  • Key mechanism: formation of an iminium electrophile, followed by attack of the enol/enolate.

  • Exam trap: distinguish it from aldol condensation; the Mannich reaction introduces an aminoalkyl group.


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