Hema prefi

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PART I. HEMOGLOBIN SYNTHESIS, STRUCTURE, AND FUNCTION
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Who identified hemoglobin as the true coloring matter of blood in 1862?
Felix Hoppe
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Who discovered that hemoglobin transports oxygen in 1904?
Christian Bohr
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Who established the structure of hemoglobin in 1912?
Küster
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Who synthesized heme in the laboratory in 1920?
Hans Fischer
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Who described abnormal hemoglobins in 1945?
Linus Pauling
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What are the four major components of hemoglobin listed in the lecture?
2,3
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What is the heme component also called?
Ferroprotoporphyrin IX
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What are the two main locations of protoporphyrin IX synthesis in nucleated red blood cells?
Mitochondria and cytoplasm
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How many amino acids are present in the alpha globin chain?
141
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How many amino acids are present in the beta globin chain?
146
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How many amino acids are present in the delta globin chain?
146
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Which globin chains are found only during embryonic development?
Epsilon and zeta chains
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Which chromosome codes for beta, gamma, epsilon, and delta globin chains?
Chromosome 11
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Which chromosome codes for alpha and zeta globin chains?
Chromosome 16
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What is the tertiary structure of globin?
One globin chain
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What type of hemoglobin defect involves amino acid substitution?
Structural or qualitative defect
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What type of hemoglobin defect involves decreased or absent production of one or more globin chains?
Quantitative defect