Nucleic Acid

Nucleic Acid

It is an unbranded polymer in which the monomer unit is nucleotide

DNA (Deoxyribonucleic acid)

RNA (Ribonucleic acid)

What are the two types of Nucleic Acid?

Nucleotide

It is a three-subunit molecule in which a pentose sugar is bonded to both a phosphate group and a nitrogen-containing heterocyclic base.

Phosphate - Sugar - Base

What is the form of a nucleotide?

Ribose

What is the sugar unit in RNA?

2’-Deoxyribose

What is the sugar unit in DNA?

The difference in groups attached at carbon 2’

What’s the difference between ribose and 2’-deoxyribose

Thymine (T), Cytosine (C), and Uracil (U)

What are the pyrimidine derivatives?

Adenine (A), Guanine (G)

What are the purine derivatives?

False

Thymine only occurs in DNA

T/F

Thymine can occur in both DNA and RNA.

True

T/F

Uracil is found only in RNA

1. Pentose Sugar

2. Nitrogen-containing heterocyclic base

3. Phosphate

What are the components of a nucleotide?

1. Between sugar and base

2. Between sugar and phosphate

In nucleotide formation, where does condensation with formation of water molecule occur?

C-1’

The base is always attached at the _______ position of the sugar

1. N-9

2. N-1

For purine bases, attachment is through (1)_______

For pyrimidine bases, attachment is through (2)_______

β-N-glycosidic linkage

The bond connecting the sugar and base is a _______

C-5’

The phosphate is attached to the sugar at the ______ through a phosphate-ester linkage.