BIO 420: Viral Oncogenes (2)

How do DNA and RNA viruses differ in copying their genome?

DNA: use host DNA pol

RNA: carry their own pol

What is an LTR?

Long terminal repeat, contains strong promoters, retrovirus

What is src? How is it inhibited?

Src is a protein kinase, v-src has higher activity bc it’s truncated before the C-term, C-term of src regulates kinase activity

Where is Src located? What does it phosphorylate?

Src is located on the inner leaflet of the plasma membrane, it phosphorylates CAV1 to promote endocytosis

What are the two ways that retroviruses can lead to tumor formation?

Hijack a cellular gene like src and transform other cells

Drive a cellular gene next to the provirus on the host chromosome

What is a nonpermissive host?

Viruses can infect cells and integrate into the genome, but cannot make new particles and lyse the cells