JAK kinases phosphorylate and activate STAT (BMED 5207 exam 4)

0.0(0)
Studied by 0 people
call kaiCall Kai
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/3

encourage image

There's no tags or description

Looks like no tags are added yet.

4 Terms

1
New cards

step 1 of JAK kinases phosphorylate and activate STAT

following JAK activation, STAT binds to a pY via the SH2 domain

2
New cards

step 2 of JAK kinases phosphorylate and activate STAT

JAK phosphorylates STAT

3
New cards

step 3 of JAK kinases phosphorylate and activate STAT

phosphorylated STAT dimerizes and moves into the nucleus

4
New cards

step 4 of JAK kinases phosphorylate and activate STAT

phosphorylated STAT binds to promoter sequences and activates transcription of target genes