5 - The peptide bond and secondary protein structure

How are peptide chains numbered from?

N terminus to C terminus

What can the primary sequence be compared to?

Against an entire database of sequences (e.g. Swiss-prot database -> reveal relationships) = bioinformatics  

What is the native conformation?

polypeptide chain folds into a single stable shape

What is the native conformation determined by?

Sequence of AA and other important factors 

What is the biological function of a protein completely dependent on?

The native conformation

What are the 2 key factors that contribute to protein structure?

Allowable bond rotation / weak non-covalent interactions

C-N peptide bond has double bond character (due to resonance) resulting in: ….?

No bond rotation around C-N bond / 6 atoms (peptide group) all lying in same plane