CHEM 4530 Section 2 PTMs

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13 Terms

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phosphorylation

Ser, Thr, Tyr, His

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acetylation

Lys, Ser, Ala, Gly, Thr, Val, Cys, Met; important in gene expression (losens)

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N-linked glycosilation

Asn

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amidation

Asn, Gln

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hydroxylation

Pro, Lys; important in collagen structure

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methylation

Lys, Arg; important in gene expression (packs)

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O-linked glycosilation

Ser, Thr

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ubiquitylation

Lys, Met

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pyrrolidone carboxylic acid

Gln

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ADP-ribosylation

residues with N, O, S; responsible for diphtheria and cholera toxin

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nucleotidylation

Thr, Ser, Tyr, Lys, His

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N-myristoylation

Gly; allows for weak protein-protein and protein-lipid interactions, occurs to make GPI anchors

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prenylation

Cys; facilitate attachment to cell membranes, protein-protein binding