26.1 MEDSCI 320 - Block 3 Drugs List

Drugs & Lipoproteins, Heart, Blood, Vascular System 1 & 2

atorvastatin [class]

Statin

simvastatin [class]

Statin

rosuvastatin [class]

Statin

bezafibrate [class]

Fibrate

cholestyramine [class]

Bile Acid Binding Resin

metoprolol [class]

Beta Antagonist (Beta Blocker)

carvedilol [class]

Non-Selective Beta Antagonist & Alpha-1 Antagonist

amiodarone [class]

Potassium Channel Blocker (Class III Antidysrhythmic)

verapamil [class]

Calcium channel blocker (cardioselective)

diltiazem [class]

Calcium channel blocker (intermediate selectivity)

isoprenaline [class]

Beta Agonist; Positive Inotrope

dobutamine [class]

Beta Agonist; Positive Inotrope

milrinone [class]

Phosphodiesterase Inhibitor

digoxin [class]

Na+/K+ ATPase Inhibitor; Positive Inotrope

heparin / LMW heparin [class]

Anticoagulant

warfarin [class]

Anticoagulant

dabigatrin [class]

Direct Oral Anticoagulant (DOAC); Unilvant Direct thrombin inhibitor

rivaroxaban [class]

Direct Oral Anticoagulant (DOAC)

tissue plasminogen activator (tPa) [class]

Fibrinolytic agent

streptokinase [class]

Fibrinolytic agent

aspirin [class]

Platelet Modifier

clopidogrel [class]

Platelet Modifier

nifedipine [class]

Calcium Channel Blocker

isosorbide mononitrate [class]

Nitrate (oral)

glyceryl trinitrate/nitroglycerin [class]

Nitrate (sublingual)

sodium nitroprusside (SNP) [class]

Nitrate (IV)

captopril [class]

ACE Inhibitor

losartan [class]

Angiotensin Receptor Antagonist/Blocker

prazosin [class]

Alpha-1 antagonist

atorvastatin [MoA]

Inhibits HMG CoA Reductase, decraeses synthesis of cholesterol which promotes uptake of LDL from bloodstream

simvastatin [MoA]

Inhibits HMG CoA Reductase, decraeses synthesis of cholesterol which promotes uptake of LDL from bloodstream

rosuvastatin [MoA]

Inhibits HMG CoA Reductase, decraeses synthesis of cholesterol which promotes uptake of LDL from bloodstream

bezafibrate [MoA]

Agonist at PPAR-alpha receptor, increases LPL activity, increases chylomicron/VLDL catabolism

cholestyramine [MoA]

Absorbs bile acids in intestine and traps there for excretion in faeces, body uses cholesterol to make more bile acids

metoprolol [MoA]

Antagonist at beta-1 adrenoceptors, decreasing cAMP production and calcium entry to cardiac cells

carvedilol [MoA]

Antagonist at beta adrenoceptors (see metoprolol); decreases vasoconstriction via alpha-1 antagonism

amiodarone [MoA]

Slows potassium influx (Phase 3) of cardiac action potential, delays repolarisation phase, slows HR

verapamil [MoA]

Block L-type calcium channels, inhibits cardiac contraction

diltiazem [MoA]

Block L-type calcium channels, inhibits cardiac contraction and vasoconstriction

isoprenaline [MoA]

Agonist at beta-1 and beta-2 receptors, increases cAMP and therefore contractile force

dobutamine [MoA]

Agonist at beta-1 and beta-2 receptors, increases cAMP and therefore contractile force; causes vasoconstriction via alpha-1 to raise blood pressure

milrinone [MoA]

Inhibits PDE 3 to reduce breakdown of cAMP, promotes cardiac contractility and vasodilation

digoxin [MoA]

Inhibits Na+/K+ ATPase, increases intracellular Na which decreases driving force of NCX, results in reduced calcium extrusion

heparin / LMW heparin [MoA]

Activates AT-III-induced inhibition of Factors II and X (LMW heparin mostly via Factor X)

warfarin [MoA]

Inhibits Vitamin K Reductase, preventing redox cycling of warfarin and therefore production of clotting factors

dabigatrin [MoA]

Inhibits activated-thrombin ability to bind to fibrinogen and form fibrin

rivaroxaban [MoA]

Directly inhibits Factor Xa, preventing conversion of prothrombin to thrombin

tissue plasminogen activator (tPa) [MoA]

Binds to fibrin on the clot, activates fibrin-bound plasminogen, plasmin is cleaved, fibrin broken down, clot dissolves

streptokinase [MoA]

Binds to fibrin (on the clot or circulating), activates plasminogen, plasmin is cleaved, fibrin broken down, clot dissolves

aspirin [MoA]

COX1 inhibitor

clopidogrel [MoA]

Inhibits binding of ADP to its platelet receptor

nifedipine [MoA]

Blocks L-type calcium channels, inhibiting vascular smooth muscle contraction

isosorbide mononitrate [MoA]

Breaks down to release NO

glyceryl trinitrate/nitroglycerin [MoA]

Breaks down to release NO

sodium nitroprusside (SNP) [MoA]

Breaks down to release NO

captopril [MoA]

Inhibits ACE, preventing conversion of Ang I to Ang II

losartan [MoA]

Antagonises AT1 receptors to inhibit the actions of Ang II

prazosin [MoA]

Antagonises alpha-1 receptors to block SNS-mediated vasoconstriction