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When are least squares coefficients unique?
Exactly when A has linearly independent columns. Even without unique coefficients the fitted vector is always unique.
What does the pseudoinverse give?
A+ times b is the unique least squares solution with smallest Euclidean norm. For a square invertible matrix the pseudoinverse equals the ordinary inverse.
A correct linear mean model with independent normal errors of mean zero and constant positive variance. The design matrix (containing predictor columns) has independent columns and more observations than fitted coefficients.