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Phosphodiester Bond
A covalent bond between nucleotides in a nucleic acid chain (polypeptide)
Sugar Phosphate Backbone
Gives nucleic acids structural framework
sequence of nitrogenous bases carries the genetic information.

DNA and RNA Directionality
Backbone = chain with two “ends,” and each end is labeled by which carbon on the sugar is free
5' end has a free phosphate group\
3' end has a free hydroxyl group (-OH)
Purines
Double ring bases
Includes adenine (A) and guanine (G)
Pyrimidine
Double ring bases
Includes cytosine (C), thymine (T) for DNA, and Uracil (U) for RNA