regulation of TFs

Homodimers

TFs that bind together and are the same protein

Heterodimers

TFs that bind together and are different proteins

coooperative binding

when two proteins need each other to bind

Nuclear Hormone Receptors

A type of TF that bind to hormones, bind to DNA as dimers and regulate transcription depending or not if they bind to a hormone

Homodimeric Nuclear hormone receptors

NHRs located in the cytoplasm. Once they bind to hormone, they migrate to nucleus and bind to the DNA. Activate Transcription

Heterodimeric NHR

Heterodimeric NHR’s that are already bound to DNA. They repress DNA in the absence of a ligand and activates the transcription with a ligand