HIV/AIDS Protease Inhibitors

Mnemonic

LAND FIRST

Protease Inhibitor Class Effects

GI: n/v/d, lipodystrophy, hyperglycemia, hyperlipidemia, increased risk of mi and bleeding in hemophiliacs, hepatotoxicity and serum transaminase

Protease Inhibitor DI

Its is a CYP 3A4 Sunstrate and Inhibitor -Rifampin is CI and most should be taken with food

Lopinavir (LPV) AND Ritonavir (RTV)

Kaletra

Kaletra Solution Storage

In fridge -solution- contains propylene glycol-CI in newborns

Atazanavir

ATZ-Reyataz

Atazanavir Precautions

AV Blockage and Nephroliathiasis and Cholelithiasis

Atazanavir DI

Viread can decrease levels and Reyataz can increase Viread levels , seperate from Antaids and PPIs by 2 hours

Nelfinavir

NFV- Viracept (can not be boosted)

Darunavir

DRV- Prezista- SULFA- w food

Combo Prezcobix

Duranavir and cobicistat (DRV/COBI)

Combo Symtuza

Darunavir and cobicistat and emtracitabine and TAF

Duranavir DI

Increases pravastatin levels, so use fluvastatin instead if needed

Fosamprenavir

FPS - LEXIVA- SULFA

Fosamprenavir Formulation without food

Oral formulation in adults and on empty stomach-with fiid with kids

Fosamprenavir CI/DI

Antacids and PPI AND SULFA

Indinavir

IDV- Crixivan

Indinavir SE

Hyperbilirubinemia and Nephrolithiasis/Urolithiasis——-Water to prevent kidney stones

Ritonavir (BOOSTER) (CONTAINS Alcohol)

RTV- Norvir - w food

Ritonavir Forulation Storage

Capsule- In fridge and Solution on shelf

Saquinavir

SQV- Invirase

Saquinavir Clinical Comments

ECG before starting therapy

Tipranavir

TPV- Aptivus

Tipranavir Black Box Warning

Intracranial Hemorrhage

Cobicistat (BOOSTER)

Tybost

COBICISTAT AND Atazanavir Combo

Evotaz

Cobicistat and Darunavir Combo

Prezcobix

Cobicistat CI

CrCl <70

Meds that contains alcohol

Kaletra, Ritonavir, and Tipranavir

Monitoring Parameters

LFTs, Glucose, Cholesterol, and Fat Redistribution