Receptors, where they're located, and effects of agonists/antagonists (Block 1)

a-1 receptor locations

vascular smooth muscle, nasal mucosa, bladder/prostate

a-1 agonist effect on vascular smooth muscle

vasoconstriction

a-1 agonist effect on nasal mucosa

vasoconstriction (decongestion)

a-1 agonist effect on bladder/prostate

contraction (treat incontinence)

a-1 antagonist effect on vascular smooth muscle

vasodilation

a-1 antagonist effect on nasal mucosa

vasodilation

a-1 antagonist effect on bladder/prostate

relaxation (treat retention)

a-2 receptor locations

CNS, vascular smooth muscle

a-2 agonist effect on CNS

decrease sympathetic response (treat HTN)

a-2 agonist effect on vascular smooth muscle

vasodilation

a-2 antagonist effect on CNS

increase sympathetic response

a-2 antagonist effect on vascular smooth muscle

vasoconstriction

B-1 receptor locations

SA node (heart), AV node (heart), kidney

B-1 agonist effect on SA node

chronotropic (increase HR)

B-1 agonist effect on AV node

dromotropic (increase conduction) and ionotropic (increase force of contraction)

B-1 agonist effect on kidney

increase rennin release (increase BP)

B-1 antagonist effect on SA node

decrease HR (treat tachycardia)

B-1 antagonist effect on AV node

decrease conduction (treat arrhythmias) and decrease contraction (treat heart failure)

B-1 antagonist effect on kidney

decrease renin release (treat HTN)

B-2 receptor locations

bronchial SM, uterine SM, vascular SM, skeletal muscle, liver

B-2 agonist effect on bronchial SM

bronchodilation

B-2 agonist effect on uterine SM

relaxation

B-2 agonist effect on vascular SM

vasodilation

B-2 agonist effect on skeletal muscle

increase tremor

B-2 agonist effect on liver

increase glycogenolysis and gluconeogenesis

B-2 antagonist effect on bronchial SM

bronchoconstriction

B-2 antagonist effect on uterine SM

contraction

B-2 antagonist effect on vascular SM

vasoconstriction

B-2 antagonist effect on skeletal muscle

decrease tremor

B-2 antagonist effect on liver

decrease glycogenolysis and gluconeogenesis

muscarinic (M) receptor locations

heart, bronchial SM, glands, GI tract, bladder, vascular SM, CNS

M agonist effect on heart

decrease HR and decrease force of contraction

M agonist effect on bronchial SM

bronchoconstriction

M agonist effect on glands

increase secretions

M agonist effect on GI tract

increase motility

M agonist effect on bladder

increase urination

M agonist effect on vascular SM

vasodilation

M agonist effect on CNS

increase cognition and increase tremor

M antagonist effect on heart

increase HR and increase force of contraction

M antagonist effect on bronchial SM

bronchodilation

M antagonist effect on glands

decrease secretions

M antagonist effect on GI tract

decrease motility

M antagonist effect on bladder

decrease urination

M antagonist effect on vascular SM

vasoconstriction

M antagonist effect on CNS

decrease cognition and decrease tremor

Neuronal nicotinic (Nn) receptor locations

CNS, autonomic ganglia

Nn agonist effect on CNS/autonomic ganglia

smoking cessation (stop smoking)

Muscular nicotinic (Nm) receptor locations

skeletal muscle

Nm agonist effect on skeletal muscle

increase muscle stimulation (can overstimulate)

Nm antagonist effect on skeletal muscle

prevents depolarization (inhibits normal functioning)