Chapter 20 - HDFN Review Questions

The etiology of HDFN is characterized by:

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a. IgM antibody

b. Nearly always anti-D

c. Different RBC antigens between mother and father

d. Antibody titer less than 32

different RBC antigens between mother and father

An important difference between the fetus and the newborn physiology is:

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a. Bilirubin metabolism

b. Maternal antibody level

c. Presence of anemia

d. Size of RBCs

bilirubin metabolism

Kernicterus is caused by the effects of:

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a. Anemia

b. Unconjugated bilirubin

c. Antibody specificity

d. Antibody titer

unconjugated bilirubin

The advantage of middle cerebral artery peak systolic velocity Doppler (MCA-PSV) is that it is:

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a. Able to measure fetal hemoglobin and hematocrit levels

b. Able to support antigen typing of fetal blood using DNA

c. Helpful for direct transfusion of fetal circulation

d. Noninvasive and decreases risk of adverse events

noninvasive and decreases risk of adverse events

Blood for intrauterine transfusion (IUT) should be:

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a. Irradiated, leukocyte reduced, more than 7 days old, HbS negative

b. Irradiated, leukocyte reduced, less than 7 days old, HbS positive

c. Irradiated, leukocyte reduced, less than 7 days old, HbS negative

d. Irradiated, leukocyte reduced, more than 7 days old, HbS positive

irradiated, leukocyte reduced, less than 7 days old, HbS negative

RhIG is indicated for:

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a. Mothers who have anti-D due to allosensitization

b. Infants who are RhD-negative

c. Infants who have anti-D

d. Mothers who are RhD-negative

mothers who are RhD-negative

RhIG is given to RhD-negative mothers without regard for fetal RhD type in all of the following conditions except:

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a. Ectopic pregnancy rupture

b. Full-term delivery

c. Amniocentesis

d. Induced abortion

full-term delivery

A Kleihauer-Betke test or flow cytometry indicates 10 fetal cells per 1,000 adult cells. For a woman with 5,000-mL blood volume, the proper dose of RhIG is:

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a. One regular-dose (300ug) vial

b. Two regular-dose vials

c. Three regular-dose vials

d. Four regular-dose vials

three regular-dose vials

ABO HDFN is usually mild because:

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a. ABO antigens are poorly developed in the fetus

b. ABO antibodies prevent the disease itself

c. ABO antibodies readily cross the placenta

d. ABO incompatibility is rare

ABO antigens are poorly developed in the fetus

A woman without prenatal care delivers a healthy term infant. A cord blood sample shows the infant is A-positive with a positive DAT. The workup of the unexpected finding should include:

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a. Anti-C3 antiglobulin test

b. ABO testing of the mother

c. Direct antiglobulin testing of the mother’s specimen

d. ABO and Rh typing of the father

ABO testing of the mother