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Aspirin (Bayer, Ecotrin)
Mechanism of Action: Anti-platelet aggregate that inhibits cyclooxygenase (COX-1 and COX-2), preventing thromboxane A2 formation and reducing blood clot formation. Indications: Suspected acute coronary syndrome, chest pain suggestive of myocardial infarction. Contraindications: Hypersensitivity to aspirin/NSAIDs, active GI bleeding, bleeding disorders, pediatric patients with viral illness. Route of Administration: Oral (chewed). Dosage:
Albuterol (MDI and Nebulizer) (Proventil, Ventolin)
Mechanism of Action: Selective beta-2 adrenergic agonist that relaxes bronchial smooth muscle and causes bronchodilation. Indications: Bronchospasm associated with asthma, COPD, or anaphylaxis. Contraindications: Hypersensitivity, severe tachycardia, digitalis toxicity. Route of Administration: Inhalation (MDI or Small-Volume Nebulizer). Dosage:
Activated Charcoal (Actidose-Aqua)
Mechanism of Action: Adsorbs ingested toxic substances in the GI tract, preventing systemic absorption. Indications: Acute oral poisonings and toxin ingestions (within 1hour). Contraindications: Altered mental status, inability to maintain airway, ingestion of acids, alkalis, or petroleum distillates. Route of Administration: Oral. Dosage:
Oxygen
Mechanism of Action: Increases arterial oxygen tension (PaO2) and improves tissue and cellular oxygenation. Indications: Hypoxia (SpO2<94%), respiratory distress, chest pain, shock, trauma, severe anemia. Contraindications: None in emergency settings. Route of Administration: Inhalation (Nasal Cannula, NRB, BVM). Dosage:
Naloxone (Narcan)
Mechanism of Action: Competitive opioid receptor antagonist that displaces opioids from CNS receptor sites, reversing respiratory and CNS depression. Indications: Suspected or known opioid overdose with respiratory depression (RR<10 breaths/min) and altered mental status. Contraindications: Hypersensitivity to naloxone. Route of Administration: Intranasal (IN), Intramuscular (IM), Subcutaneous (SQ). Dosage:
Oral Glucose (Glutose, Insta-Glucose)
Mechanism of Action: Direct absorption of simple carbohydrate to rapidly elevate blood glucose levels. Indications: Hypoglycemia (BG<60mg/dL) in conscious patients with altered mental status. Contraindications: Unconsciousness, inability to swallow, compromised airway. Route of Administration: Buccal / Oral. Dosage:
Nitroglycerin (Nitrostat, Nitro-Bid)
Mechanism of Action: Vascular smooth muscle relaxant and vasodilator that reduces preload, afterload, and myocardial oxygen demand. Indications: Chest pain of cardiac origin (angina, acute myocardial infarction). Contraindications: Systolic BP <100mmHg, severe bradycardia or tachycardia, erectile dysfunction drug use within 24 to 48hours, intracranial hemorrhage. Route of Administration: Sublingual (tablet or spray). Dosage:
Epinephrine 1:1000 (Adrenalin)
Mechanism of Action: Non-selective adrenergic agonist causing vasoconstriction (α1), bronchodilation (β2), and increased cardiac output (β1). Indications: Severe allergic reactions, anaphylaxis, severe acute asthma. Contraindications: None in life-threatening anaphylaxis. Route of Administration: Intramuscular (IM). Dosage:
Epi-pen
Mechanism of Action: Auto-injector delivery of epinephrine causing vasoconstriction, bronchodilation, and increased cardiac output. Indications: Severe allergic reactions and anaphylaxis in adult patients. Contraindications: None in life-threatening anaphylaxis. Route of Administration: Intramuscular (IM) auto-injector. Dosage:
Epi-pen Jr
Mechanism of Action: Pediatric auto-injector delivery of epinephrine causing vasoconstriction, bronchodilation, and increased cardiac output. Indications: Severe allergic reactions and anaphylaxis in pediatric patients weighing 15 to 30kg. Contraindications: None in life-threatening anaphylaxis. Route of Administration: Intramuscular (IM) auto-injector. Dosage: