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What is the leading preventable cause of disease and premature death in the U.S.?
Tobacco use
About how many U.S. deaths per year are caused by tobacco use?
480,000
How did the Mayans view tobacco smoke?
"Divine incense"
Who called tobacco an "infallible cure"?
Nicholas Monardes
What did Pope Urban VII threaten tobacco users with?
Excommunication
When did cigars become popular in the U.S.?
Early 1800s
Why did the cigarette-rolling machine increase cigarette use?
It made cigarettes cheaper
What is the primary tobacco species?
Nicotiana tabacum
What happened in 1964 involving smoking?
Surgeon General linked smoking to lung cancer
What happened to cigarettes in 1970?
Warning labels were added
What did the Family Smoking Prevention and Tobacco Control Act do?
Gave FDA authority over tobacco products
What is nicotine?
A colorless alkaloid
What neurotransmitter does nicotine stimulate the release of?
Dopamine
What is vaping?
Inhaling vapor from an e-cigarette
What is smokeless tobacco strongly associated with?
Leukoplakia
How many cancer-causing agents are in chewing tobacco/snuff?
28
What is secondhand smoke?
Smoke from the burning product + exhaled smoke
What is passive smoking?
Nonsmokers inhaling tobacco smoke
What are hallucinogens?
Drugs that alter sensory processing and perception
What is synesthesia?
Mixing/crossing of sensory experiences
What are flashbacks?
Recurrence of hallucinogenic experiences
What 1978 law is associated with the Native American Church?
American Indian Religious Freedom Act
Who founded the League of Spiritual Discovery?
Timothy Leary
What does LSD stand for?
Lysergic acid diethylamide
What is pure LSD like?
Colorless, odorless, tasteless
What are common street names for LSD?
Acid, blotter acid, microdot, windowpanes
What neurotransmitter system does LSD mainly affect?
Serotonin
Does LSD cause physical dependence?
No
How soon do LSD effects begin?
30-90 minutes
How long can LSD effects last?
Up to 12 hours
How quickly does LSD tolerance develop?
Very quickly
What is mescaline found in?
Peyote cactus
What is the main source of psilocybin?
Psilocybe mexicana mushroom
What is DMT?
A short-acting hallucinogen
What is MDMA also called?
Ecstasy
What is an entactogen?
A drug with psychedelic + stimulant effects
What was PCP originally developed as?
An anesthetic
What replaced PCP as a safer analog?
Ketamine
What is dextromethorphan normally used as?
A cough suppressant
Why are stimulants called "uppers"?
They increase alertness, excitation, and euphoria
When was amphetamine first synthesized?
1887
Who first synthesized amphetamine?
L. Edeleano
Who described amphetamine's effects in 1927?
Gordon Alles
What became available OTC in 1932?
Benzedrine inhalers
Why were amphetamines used in WWII?
To fight fatigue
What are 3 approved uses of amphetamines?
Narcolepsy, ADHD, weight reduction
What does "ice" refer to?
Smoked methamphetamine
What is behavioral stereotypy?
Meaningless repetition of one activity
What are the 3 stages of cocaine withdrawal?
Crash, withdrawal, extinction