3.4 When to start treatment? SLIDE 71

What type of statin is recommended for Group 1?

High-intensity statin

In very high-risk Group 1 patients, when should PCSK9 or ezetimibe be added?

If LDL remains ≥55 mg/dL or

In not high-risk Group 1 patients, when should ezetimibe or PCSK9 be added?

If LDL remains ≥70 mg/dL or

What type of statin is recommended for Group 2?

High-intensity statin

When should ezetimibe or PCSK9 be added for Group 2?

If LDL doesn't decrease by 50% or remains ≥100 mg/dL

What is the minimum intensity for Group 3?

Moderate-intensity statin

At what ASCVD risk should Group 3 receive high-intensity statin?

If risk ≥7.5% or risk enhancers present

When should high-intensity be used with ezetimibe in Group 3?

If risk ≥20%, LDL reduction

What statin intensity is used for Group 4?

Moderate-intensity statin

What is the LDL target range for Group 4 (risk 7.5-20%)?

Target 30-49% LDL reduction and LDL

When should Group 4 escalate to high-intensity statin?

If risk ≥20%, target ≥50% LDL reduction and LDL

When is add-on therapy considered in Group 4?

If needed to reach LDL targets after high-intensity statin